← Back to Search

Neuromodulation Device

Active rTMS for Depression (TPD Trial)

N/A
Waitlist Available
Led By Mark K Greenwald, PhD
Research Sponsored by Wayne State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from pre- to 50-minutes post-rtms stimulation in each session
Awards & highlights

TPD Trial Summary

This trial is testing the feasibility and efficacy of using repetitive transcranial magnetic stimulation (rTMS) to treat substance use disorders. rTMS is a neuromodulation device that uses a safe, electromagnetic field on the scalp to increase or decrease neuronal communication and activity. This pilot project will help the research team gather data to plan longer-term studies focusing on populations with substance use disorders.

Eligible Conditions
  • Depression
  • Pain
  • Executive Dysfunction

TPD Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from pre- to 50-minutes post-rtms stimulation in each session
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from pre- to 50-minutes post-rtms stimulation in each session for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Delay Discounting Task (cognitive control)
Pain Sensitivity
Stop Signal Task (impulsivity)
+1 more
Secondary outcome measures
Effort Choice Task (motivation)
Monetary Incentive Delay Task (motivation)
Mood
+1 more

TPD Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Active rTMSActive Control1 Intervention
Active rTMS will be applied over the left dorsolateral prefrontal cortex using an active figure of 8 coil (within-subject crossover). In the active rTMS condition, the investigators will use high-frequency (10Hz) dorsolateral prefrontal cortex (dlPFC) stimulation with intensity of 110% of resting motor threshold. rTMS will consist of 120 trains with 50 stimuli per train (i.e. 5-sec long at 10 Hz) and 10-sec intertrain interval for a total of 6000 pulses. The entire protocol will last 30 min (120 trains with 5-sec on/10-sec off).
Group II: Sham rTMSPlacebo Group1 Intervention
Sham rTMS will be applied over the left dorsolateral prefrontal cortex using a sham figure of 8 coil (within-subject crossover). Sham rTMS will consist of the same auditory and tactile stimuli as the active condition, but does not induce an electromagnetic field and does not affect cortical excitability.

Find a Location

Who is running the clinical trial?

Wayne State UniversityLead Sponsor
307 Previous Clinical Trials
108,464 Total Patients Enrolled
5 Trials studying Depression
9,236 Patients Enrolled for Depression
Mark K Greenwald, PhDPrincipal InvestigatorWayne State University
5 Previous Clinical Trials
284 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To be eligible for this test, what requirements must a patient meet?

"To qualify for this study, participants must experience pain and be between 21-60 years old. The trial is looking to enroll approximately 30 people in total."

Answered by AI

What is the expected outcome of this experiment?

"The trial's primary outcome will be 50-minute post-rTMS stimulation results on the Stroop Test, which is a cognitive control assessment. Additionally, researchers will measure motivation with the Effort Choice Task and BDNF/prolactin levels to assess for changes in peripheral biomarkers. Lastly, investigators will also use the Positive and Negative Affect Schedule to record any changes in mood state."

Answered by AI

Could you tell me if this research is only open to those under 30 years of age?

"The requirements to participate in this clinical trial state that applicants must be between 21 and 60 years old. There are 89 other trials for patients under 18 and 288 for those over 65."

Answered by AI

Are we still looking for test subjects for this research?

"This trial is currently looking for patients to enroll, according to the website clinicaltrials.gov. The study was first advertised on August 13th, 2019 and updated September 8th, 2021."

Answered by AI

Who else is applying?

What state do they live in?
Michigan
What site did they apply to?
Wayne State University
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+
Recent research and studies
clinicaltrials.govStudy
Feasibility and Efficacy of rTMS in Healthy Persons
Mark Greenwald, PhD 2023. "Feasibility and Efficacy of rTMS in Healthy Persons". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04074811.
~0 spots leftby Apr 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top