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Local Anesthetic

2% lidocaine for Post-Dural Puncture Headache (SPGB Trial)

N/A
Waitlist Available
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

SPGB Trial Summary

This trial will compare whether early intervention sphenopalatine ganglion block (SPGB) with the option for repeat, patient self-administered SPGBs versus current standard conservative management can reduce the severity and duration of postdural puncture headache (PDPH) pain and improve patient functional status.

Eligible Conditions
  • Post-Dural Puncture Headache

SPGB Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Enrollment rate

SPGB Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: SPGBExperimental Treatment1 Intervention
Via a soft tip 20-gauge long IV catheter attached to a 3 mL syringe will be filled with 2 mL of 2% viscous lidocaine. The 2% viscous lidocaine will be administered according to the method of Barre.
Group II: PlaceboPlacebo Group1 Intervention
It will be adminstered the same as the experimental arm but with methylcellulose and cherry flavouring to match odour and taste.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
2% lidocaine
2007
Completed Phase 4
~360

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
884 Previous Clinical Trials
2,598,316 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the predominant reasons to administer 2% lidocaine?

"2% lidocaine is often used to manage cervical syndrome, but can also provide relief for minor burns, transplantation procedures, and even osteoporosis."

Answered by AI

Is there an ongoing effort to find participants for this trial?

"Affirmative. Analysis of the clinicaltrials.gov website reveals that this research is actively recruiting participants; it was first posted on December 1st 2021 and most recently updated on August 23rd 2022. 22 people are required from 1 medical centre to complete the trial."

Answered by AI

Is this medical experiment enrolling individuals of advanced age?

"This research trial is open to individuals older than 18 and younger than 45 years old."

Answered by AI

Is it possible for me to partake in this clinical trial?

"In order to qualify for this clinical study, individuals must be between 18 and 45 years old with postdural puncture headache. Approximately 22 participants are needed for the trial."

Answered by AI

What is the aggregate population size for this research project?

"Affirmative. Clinicaltrials.gov hosts data indicating that this research is currently seeking volunteers. It was first posted on December 1st 2021 and most recently updated August 23rd 2022, with the aim of enrolling 22 individuals from a single clinical centre."

Answered by AI

Have any other experiments been conducted to assess the impact of 2% lidocaine?

"Presently, there are 119 ongoing trials for 2% lidocaine; of these, 31 have progressed to Phase 3. Although the majority of research is organized in Calgary, Alberta, a total of 1096 clinical sites worldwide are running studies for this medication."

Answered by AI
Recent research and studies
Canadian Journal of Anesthesia/Journal canadien d'anesthésieJournal
PDPH Is a Common Complication of Neuraxial Blockade in Parturients: A Meta-analysis of Obstetrical Studies
Choi, Peter T., Saramin E. Galinski, Lawrence Takeuchi, Stefan Lucas, Carmen Tamayo, and Alejandro R. Jadad. 2003. “PDPH Is a Common Complication of Neuraxial Blockade in Parturients: A Meta-analysis of Obstetrical Studies”. Canadian Journal of Anesthesia/journal Canadien D'anesthésie. Springer Science and Business Media LLC. doi:10.1007/bf03021057.
Canadian Journal of Anesthesia/Journal canadien d'anesthésieJournal
Expectant Management of Postdural Puncture Headache Increases Hospital Length of Stay and Emergency Room Visits
Angle, Pamela, Dorothy Thompson, John Paul Szalai, and Samuel Lap Tak Tang. 2005. “Expectant Management of Postdural Puncture Headache Increases Hospital Length of Stay and Emergency Room Visits”. Canadian Journal of Anesthesia/journal Canadien D'anesthésie. Springer Science and Business Media LLC. doi:10.1007/bf03016283.
Headache: The Journal of Head and Face PainJournal
Cocaine as an Abortive Agent in Cluster Headache
Barre', Felix. 1982. “Cocaine as an Abortive Agent in Cluster Headache”. Headache: The Journal of Head and Face Pain. Wiley. doi:10.1111/j.1526-4610.1982.hed2202069.x.
Saudi Journal of AnaesthesiaJournal
Transnasal Sphenopalatine Ganglion Block for the Treatment of Postdural Puncture Headache Following Spinal Anesthesia
Channabasappa, ShivakumarM, Shonali Manjunath, Basavaraj Bommalingappa, Sreenivas Ramachandra, and S Banuprakash. 2017. “Transnasal Sphenopalatine Ganglion Block for the Treatment of Postdural Puncture Headache Following Spinal Anesthesia”. Saudi Journal of Anaesthesia. Medknow. doi:10.4103/sja.sja_59_17.
~0 spots leftby May 2025
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