CBT MobileWork-V plus CBT for Depression

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, PA
Depression+1 More
CBT MobileWork-V plus CBT - Behavioral
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This study is evaluating whether a smartphone app may help veterans with depression.

See full description

Eligible Conditions

  • Depression

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Depression

Study Objectives

This trial is evaluating whether CBT MobileWork-V plus CBT will improve 1 primary outcome and 1 secondary outcome in patients with Depression. Measurement will happen over the course of baseline and weekly up to 12 weeks.

Week 12
Patient Health Questionnaire (PHQ-9) Change
Month 9
Skills of Cognitive Therapy (Patient Version) Change

Trial Safety

Safety Progress

1 of 3

Other trials for Depression

Trial Design

2 Treatment Groups

CBT-D
1 of 2
CBT-D augmented with CBT MobileWork-V
1 of 2
Active Control
Experimental Treatment

This trial requires 268 total participants across 2 different treatment groups

This trial involves 2 different treatments. CBT MobileWork-V Plus CBT is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

CBT-D augmented with CBT MobileWork-V
Behavioral
Patients randomized to this condition will receive CBT-D as usual plus access to CBT MobileWork-V, a comprehensive tailored smartphone app for CBT skills practice for OEF/OIF Veterans.
CBT-DPatients randomized to CBT-D will receive CBT-D as usual only.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, week 12, and month 9
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline, week 12, and month 9 for reporting.

Closest Location

VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA - Pittsburgh, PA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Veteran of OEF/OIF/OND deployments
Depressive severity of at least 10 on the PHQ-9 at screening (Patient may also have a DSM-5 56 diagnosis of unipolar Major Depression; PTSD; any anxiety disorder; substance/alcohol abuse; or adjustment disorder)
Ability to read at the eighth grade level and to provide informed consent
Patients may be taking antidepressants or antianxiety medications where dose has been stable for at least 4 weeks prior to screening evaluation
Must have an Android smartphone
Must be willing to be audio-taped for fidelity ratings

Patient Q&A Section

How many people get depression a year in the United States?

"This was the first study to look at the question of the annual number of cases of depression in the United States. We conclude that the estimate of the annual number we obtained, i.e., 1.2 million to 1.6 million per year, more or less approximates the number of new cases of major depression per year. The prevalence rate of major depression remains high. Only one of the four methods we used gave an estimate that was appreciably below the number we found." - Anonymous Online Contributor

Unverified Answer

What are the signs of depression?

"Symptoms of depression include low energy, increased appetite and overeating, weight gain or loss, insomnia or hypersomnia, mood swings, loss of interest in sex and difficulties in concentrating. It can sometimes affect all day’s activities and cause a loss of interest in socialising.\n\nSymptoms of depression often occur first or after other medical issues or stressful life events have had time to worsen. Causes of depression are often multiple and the underlying mechanism is not yet fully understood. One of the most common psychiatric conditions is depression which is caused by a variety of causes. Depression can be physical or non-physical such as a chemical imbalance and can affect the mind of an individual and their life." - Anonymous Online Contributor

Unverified Answer

What causes depression?

"The causes of depression are various and complex, but mood disorders are frequently treatable and can be prevented through intervention with medical professionals or through complementary therapy. Depression is the most widely experienced chronic mental health condition, and unfortunately it is also one of the most neglected conditions in terms of knowledge and treatment." - Anonymous Online Contributor

Unverified Answer

What is depression?

"The causes of depression are varied and complex, but there is an underlying tendency toward neurophysiological dysfunction, especially in the prefrontal cortex and basal ganglia, which affects the function of all regions of the central nervous system and results in poor coping and behavioural responses.\n" - Anonymous Online Contributor

Unverified Answer

What are common treatments for depression?

"There are no "cure-all" antidepressants, but some antidepressants are specifically indicated for depression. In addition, there is evidence they may be effective for the treatment of depression. Also, there is some evidence that CBT and interpersonal psychotherapy may also have some efficacy in the treatment of depression. There is some evidence that these treatments may be more effective in relieving depression in women. There is no evidence to support the use of antidepressants or psychotherapy for depression with anemia; however, there is some evidence suggesting that they may reduce the risk of developing depression in women with anemia. Some antidepressants may be more effective in the treatment of depression, but these conclusions still require prospective study." - Anonymous Online Contributor

Unverified Answer

Can depression be cured?

"From this small case series, we conclude that patients can expect improvement in depressive symptoms after a brief trial of psychotherapy. Further research is needed on the most effective procedures that lead to remission." - Anonymous Online Contributor

Unverified Answer

What is the latest research for depression?

"Results from a recent clinical trial are significant because the majority of published research on depression is focused on psychopharmacological or nonpharmacological therapies. This is inconsistent with our clients' most effective treatments. Our goal is to help professionals who provide treatment for depression take a more proactive approach when addressing the research on antidepressant therapy. We hope our data help professionals and patients become more proactive in applying scientifically validated antidepressant therapy to their problems. Finally, we anticipate our data will help researchers to develop more effective nonpharmacological therapies." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of cbt mobilework-v plus cbt?

"Cognitive behavioral therapy is a valid form of treatment for depression, but CBT-mV+CBT was found to improve mood and functioning (and to reduce the duration) more than the CBT-only groups on some measures." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of depression?

"Everyone has their own cause but they have not been identified yet... The number of causes is limited but there are multiple influences. The biggest issue is to see how to identify the reasons for depression and intervene.  Everyone has their own cause but they have not been identified yet...  A link between depression and the use of drugs - that has been studied by R.A.W." - Anonymous Online Contributor

Unverified Answer

Does depression run in families?

"Results from a recent paper suggest that a gene-by-environment interaction underlies the familial genetic risk of depression and is not the result of familial genetic influences on individual’s levels of depression." - Anonymous Online Contributor

Unverified Answer

Is cbt mobilework-v plus cbt safe for people?

"We conclude that the CBT mobilework-v + CBT mobilecall program (cbt m-n) appears to be safe and effective in reducing symptom scores, particularly during the first part of the intervention. Data from a recent study also shows that people can successfully gain and maintain remission from depression whilst participating in a mobilehealth intervention." - Anonymous Online Contributor

Unverified Answer

What is cbt mobilework-v plus cbt?

"In all cbt services, people's experiences of the service appear to be, at least superficially, positive, and those in whom the intervention was successful report a clear improvement in mental health. However, there is no evidence that this result was found for all people. It is possible that differences in the way that cbt services deliver their interventions could account for the difference between those who report improvement and those in whom changes are made without change in health, or it could be that cbt mobilework-v plus cbt can be said to be more effective than cbt alone. There are many potential areas for innovation with cbt services. Those who are prescribed cbt may not have access to services that can meet their needs." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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