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Dietary Supplement

Low-to-High group for Cardiovascular Disease (EVOO Trial)

N/A

Waitlist Available

Led By Ralph Hamill, MD

Research Sponsored by Ralph Hamill

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up blood pressure will be measured in each subject within 28 days before and within 28 days after consuming either low or high polyphenol evoo.

Awards & highlights

EVOO Trial Summary

This trial will study the effect of extra virgin olive oil on heart health by measuring cholesterol levels and inflammation markers in people with cardiovascular disease. The olive oils used will differ in polyphenol concentration, and investigators expect that the oil with higher polyphenol levels will have a greater positive effect.

EVOO Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ heart rate will be measured in each subject within 28 days before and within 28 days after consuming either low or high polyphenol evoo.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~heart rate will be measured in each subject within 28 days before and within 28 days after consuming either low or high polyphenol evoo.

This trial's timeline: 3 weeks for screening, Varies for treatment, and heart rate will be measured in each subject within 28 days before and within 28 days after consuming either low or high polyphenol evoo. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

HDL

Secondary outcome measures

Blood pressure

CRP

Heart rate

+2 more

EVOO Trial Design

2Treatment groups

Experimental Treatment

Group I: Low-to-High groupExperimental Treatment2 Interventions

As this is a crossover study, each participant will be assigned to each treatment intervention. Participants (randomly) assigned to Arm 1 will first receive low polyphenol concentration EVOO for consumption, followed by high polyphenol concentration EVOO for consumption following a 14- day washout phase.

Group II: High-to-Low groupExperimental Treatment2 Interventions

As this is a crossover study, each participant will be assigned to each treatment intervention. Participants (randomly) assigned to Arm 2 will first receive high polyphenol concentration EVOO for consumption, followed by low polyphenol concentration EVOO for consumption following a 14- day washout phase.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Low polyphenol concentration extra virgin olive oil (EVOO)

2021

N/A

~30

High polyphenol concentration extra virgin olive oil (EVOO)

2021

N/A

~30

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Ralph HamillLead Sponsor

Ralph Hamill, MDPrincipal InvestigatorMaine Medical Partners

1 Previous Clinical Trials

13 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research initiative still looking for participants?

"According to the public records on clinicaltrials.gov, enrolment for this trial is still available and was initially posted on July 26th 2021 with a recent update of June 9th 2022."

Answered by AI

How many people are enrolled in the current clinical experiment?

"Affirmative. The information found on clinicaltrials.gov reveals that, as of June 9th 2022, this medical trial is recruiting participants; having been initially posted on July 26th 2021. It requires 90 volunteers from 3 distinct sites to be enrolled in the study."

Answered by AI

Recent research and studies

The American Journal of CardiologyJournal

Relation Between High-density Lipoprotein Cholesterol and Survival to Age 85 Years in Men (from the VA Normative Aging Study)

Rahilly-Tierney, Catherine R., Avron Spiro III, Pantel Vokonas, and J. Michael Gaziano. 2011. “Relation Between High-density Lipoprotein Cholesterol and Survival to Age 85 Years in Men (from the VA Normative Aging Study)”. The American Journal of Cardiology. Elsevier BV. doi:10.1016/j.amjcard.2010.12.015.

InflammopharmacologyJournal

Phenolic Compounds in Olive Oil: Antioxidant, Health and Organoleptic Activities According to Their Chemical Structure

Servili, M., S. Esposto, R. Fabiani, S. Urbani, A. Taticchi, F. Mariucci, R. Selvaggini, and G. F. Montedoro. 2009. “Phenolic Compounds in Olive Oil: Antioxidant, Health and Organoleptic Activities According to Their Chemical Structure”. Inflammopharmacology. Springer Science and Business Media LLC. doi:10.1007/s10787-008-8014-y.

Journal of the American College of CardiologyJournal

The Bitter Taste of Extra Virgin Olive Oil for a Sweet Long Life

Estruch, Ramon, Rosa M. Lamuela-Raventós, and Emilio Ros. 2020. “The Bitter Taste of Extra Virgin Olive Oil for a Sweet Long Life”. Journal of the American College of Cardiology. Elsevier BV. doi:10.1016/j.jacc.2020.02.043.

Annals of Internal MedicineJournal