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HHFNC for Bronchiolitis (HHFNC Trial)

N/A
Waitlist Available
Led By Donna Milner, MD
Research Sponsored by Children's Hospitals and Clinics of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up study specific
Awards & highlights

HHFNC Trial Summary

Bronchiolitis is a common cold weather seasonal respiratory illness affecting infants and children. Multiple supportive therapies have been tried in infants with bronchiolitis including albuterol, racemic epinephrine, hypertonic saline nebulization, but to date supportive therapy with oxygen is the only proven therapy to decrease respiratory distress in infants with bronchiolitis, with hypertonic saline showing a borderline statistically significant improvement. This prospective, randomized study will compare CSS and PEWS scores on infants who receive oxygen by standard flow nasal cannula and to those who receive oxygen via Humidified High-Flow Nasal Cannula (HHFNC). The results will help determine if infants with viral bronchiolitis who receive humidified high flow nasal cannula oxygen therapy have improved Clinical Severity Score (CSS) and Pediatric Early Warning System (PEWS) scores and ultimately decreased lengths of admissions when compared to patients treated with nasal cannula oxygen therapy with/without bronchodilator therapy. Hypothesis Heated Humidified High-flow Nasal Cannula Delivery of Oxygen decreases respiratory distress as measured by pediatric CSS and PEWS when compared with routine nasal cannula oxygen delivery in infants with bronchiolitis.

Eligible Conditions
  • Bronchiolitis
  • Hypoxia

HHFNC Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~study specific
This trial's timeline: 3 weeks for screening, Varies for treatment, and study specific for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
CSS Scores
Secondary outcome measures
PEWS Score
Other outcome measures
Oxygen needs

HHFNC Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: HHFNCExperimental Treatment1 Intervention
Heated High Flow arm
Group II: Standard Nasal CannulaActive Control1 Intervention
Standard treatment
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Oxygen delivery
2015
N/A
~200

Find a Location

Who is running the clinical trial?

Children's Hospitals and Clinics of MinnesotaLead Sponsor
65 Previous Clinical Trials
5,022,183 Total Patients Enrolled
Donna Milner, MDPrincipal InvestigatorChildren's Hospitals and Clinics of Minnesota

Frequently Asked Questions

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~4 spots leftby May 2025