← Back to Search

Surgery and Post-Operative Radiation Therapy for Bone Metastases (EXPLORE Trial)

N/A
Waitlist Available
Led By Patrick Henry, MD FRCS(C)
Research Sponsored by Sunnybrook Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up weeks 2 & 6, months 3, 6, 12, 18, and 24
Awards & highlights

EXPLORE Trial Summary

This trial will compare the health outcomes of patients receiving radiation therapy after Orthopaedic surgery to patients who will not receive radiation therapy post-surgery. The primary objective of the study is to compare the need for a subsequent surgery at the same treatment site within 12 months of the initial surgery.

Eligible Conditions
  • Bone Metastases
  • Lower Extremity Fractures
  • Pathological Fracture
  • Fractures

EXPLORE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~weeks 2 & 6, months 3, 6, 12, 18, and 24
This trial's timeline: 3 weeks for screening, Varies for treatment, and weeks 2 & 6, months 3, 6, 12, 18, and 24 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Subsequent surgery after primary surgery
Secondary outcome measures
Cost-effectiveness
Overall survival
Post-operative functional status and Karnofsky Performance Status (KPS)
+5 more

EXPLORE Trial Design

2Treatment groups
Active Control
Group I: Surgery AloneActive Control1 Intervention
Patients with lower extremity bone metastases will receive surgical fixation/reconstruction but will not receive any post-operative radiation therapy.
Group II: Surgery and Post-Operative Radiation TherapyActive Control1 Intervention
Patients with lower extremity bone metastases will receive surgical fixation/reconstruction and will receive any post-operative radiation therapy.

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor
656 Previous Clinical Trials
1,551,308 Total Patients Enrolled
1 Trials studying Bone Metastases
10 Patients Enrolled for Bone Metastases
Patrick Henry, MD FRCS(C)Principal InvestigatorSunnybrook Health Sciences Centre

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment still available for this investigation?

"According to the information hosted on clinicaltrials.gov, this trial is no longer actively recruiting patients. The study was initially posted in October 2020, with its last update occurring in April of that year. Although currently not searching for participants, 1029 other trials are still open and accepting candidates."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
External Beam Radiation Therapy Post Surgery in Patients With Lower Extremity Bone Metastases Randomized Efficacy Trial
2020. "External Beam Radiation Therapy Post Surgery in Patients With Lower Extremity Bone Metastases Randomized Efficacy Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04109937.
~0 spots leftby Oct 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top