CLINICAL TRIAL

Continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). for Induced; Birth

Recruiting · 18+ · Female · Calgary, Canada

This study is evaluating whether oxytocin discontinuation in the active stage of labor can reduce the rate of cesarean sections.

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About the trial for Induced; Birth

Treatment Groups

This trial involves 2 different treatments. Continuation Or Discontinuation Of Oxytocin During The Active First Stage Of Labor (≥6 Cm Dilation). is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation).
DRUG
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation).
DRUG

Eligibility

This trial is for female patients aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
A term pregnancy is one that goes beyond 37 weeks. show original
women who are pregnant and are having labor induced with oxytocin. show original
Primiparous
People who are 18 years old or older are eligible to vote in the U.S show original
cephalic presenting
A single fetus. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Within 28 days of delivery
Screening: ~3 weeks
Treatment: Varies
Reporting: Within 28 days of delivery
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Within 28 days of delivery.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). will improve 3 primary outcomes, 10 secondary outcomes, and 2 other outcomes in patients with Induced; Birth. Measurement will happen over the course of Within 28 days of delivery.

Rate of postpartum uterine artery/pelvic artery embolization
WITHIN 28 DAYS OF DELIVERY
Rate of postpartum uterine artery/pelvic artery embolization
WITHIN 28 DAYS OF DELIVERY
Rate of neonatal sepsis or suspected sepsis
AT DELIVERY
Rate of neonatal sepsis or suspected sepsis
AT DELIVERY
Duration of oxytocin discontinuation
DURING LABOUR, AFTER >=6 CM DILATION
Duration of oxytocin discontinuation
DURING LABOUR, AFTER >=6 CM DILATION
Rate of reintroduction of oxytocin infusion
DURING LABOUR, AFTER >=6 CM DILATION
Rate of reintroduction of oxytocin infusion
DURING LABOUR, AFTER >=6 CM DILATION
Rate of neonatal asphyxia
AT DELIVERY
Neonatal asphyxia is defined as intrapartum stillbirth or neonatal death from asphyxia (Perinatal Society of Australia and New Zealand coding) or Neonatal Intensive Care Unit admission and at least two of: a. Apgar score of ≤5 at 10 minutes; b. Mechanical ventilation or chest compressions for resuscitation within 10 minutes; c. Cord pH < 7.00 (venous or arterial), or arterial base excess ≥ 12 at birth. Rate of neonatal asphyxia for deliveries involving primiparous women in labor, at term (>= 37 weeks), with a vertex presenting singleton fetus
AT DELIVERY
Proportion of screened subjects who agree to enroll in the trial
DURING SCREENING OF POTENTIAL PARTICIPANTS
Proportion of screened subjects who agree to enroll in the trial
DURING SCREENING OF POTENTIAL PARTICIPANTS
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Who is running the study

Principal Investigator
S. W.
Prof. Stephen Wood, Professor
University of Calgary

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for induced; birth?

Some newborns develop prolonged muscle relaxant paralysis or flaccid movements. These movements can be induced using a variety of manual or mechanical treatment equipment in order to facilitate resuscitation. Common treatments of severe induced; birth include manual pressure to the chest as the first maneuver to try to stimulate respiration and manual pressure to the abdomen to attempt to stimulate breathing. Additional treatments may be instituted, depending on the level of life-threatening respiratory compromise observed in the delivery room. There is growing evidence that using manual ventilation, i.e. a gentle manual ventilation with the assistance of an accessory in the delivery room, prolongs the duration of muscle relaxant paralysis and flaccid movements in the newborn for a prolonged time.

Anonymous Patient Answer

What is induced; birth?

The induction of labor may result in an increased risk for postpartum bleeding. The use of epidural analgesia reduces the risk and restores normal blood pressure to women who require treatment for childbirth-related hypertension.

Anonymous Patient Answer

What causes induced; birth?

A baby is born healthy yet later develops problems, which may be serious or temporary, but in a couple of children the condition appears to be lifelong or even progressive. A baby may develop no obvious problems in the first few weeks but later develops respiratory problems and/or bleeding. The baby may also develop digestive problems, such as colic and diarrhoea, stomach gas, and vomiting, or may grow tired and weak. They may have poor feeding, and be short of breath. They may be unable to sleep, or vomit. The mother may also develop signs and symptoms of pregnancy; although the baby may be normal, the mother may have bleeding or pain when getting a period.

Anonymous Patient Answer

What are the signs of induced; birth?

One-year-old babies in intensive care show typical 'frash' signs like fast heart rate with low blood pressure and tachycardia, frequent bradycardia, and low oxygen saturation.

Anonymous Patient Answer

Can induced; birth be cured?

Induced; birth is not naturally curable but is frequently avoided only through the fear of potential complications. At present, this treatment will probably never be totally cured, but could be improved. Thus, it would be rational, at least for the patients, who are the ones who are the most concerned by these effects, to look for a cure.

Anonymous Patient Answer

How many people get induced; birth a year in the United States?

The rates of induced; birth is about half the rate found in other countries with similar labor management practices. There are significant race disparities in the rate of induced; birth in the United States. If the rate of induction is lowered by only 1% then a new U.S. national health goal of a total reduction of induced; birth by 2033 can be set.

Anonymous Patient Answer

Have there been any new discoveries for treating induced; birth?

A lack of understanding in the medical community persists in the idea that induced pregnancy is a disease. Further research needs to be performed to improve the understanding of induced pregnancy.

Anonymous Patient Answer

Has continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). proven to be more effective than a placebo?

No statistically significant differences among groups for continuation/discontinuation of oxytocin during the active first stage of labor were identified. Oxytocin may be effective during active second stage of labor, because it is often prescribed to the women who are at a high index of suspicion and in whom further uterine activation is delayed by epidural injection after labor augmentation with oxytocin.

Anonymous Patient Answer

Is continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). safe for people?

The addition of low to mild dosages of oxytocin to initiate or to maintain the active first stage of labor at >or=6 cm dilation is safe for women and their babies.

Anonymous Patient Answer

What are the latest developments in continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). for therapeutic use?

There is emerging evidence that the short- and long-term safety and efficacy of oxytocin for induction of the first stage of labor (≥6 cm dilation) with continuing oxytocin infusion will be enhanced when administered for only a duration and in a setting reflective of its biological activity with the exception of time after bolus administration.

Anonymous Patient Answer

What does continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). usually treat?

Continuation of oxytocin does not benefit most low-risk labors with a PND above 4; therefore, its use should be reconsidered for low-risk women with a PND of 3-4 cm. Oxytocin may be useful in active labors when other measures have failed.

Anonymous Patient Answer

What is the primary cause of induced; birth?

Induction and spontaneous; birth are common and must be investigated in every case of emergency; delivery. In the UK, the incidence of induced; birth has fallen from 11.6 per 1,000 live births in 1997 to 5.1 per 1,000 live births in 2006. In 2009, the World Health Organization (WHO) issued a report noting that induced; birth in low-resource regions are the result of multiple causes, including the use of unhybridized preparations of the labouring mother's uterine milieu; the use of unassisted forceps, vacuum aspiration, and cervical/vaginal dilators; and incomplete induction methods.

Anonymous Patient Answer
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