Continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). for Induced; Birth
This study is evaluating whether oxytocin discontinuation in the active stage of labor can reduce the rate of cesarean sections.
See full descriptionAbout the trial for Induced; Birth
Treatment Groups
This trial involves 2 different treatments. Continuation Or Discontinuation Of Oxytocin During The Active First Stage Of Labor (≥6 Cm Dilation). is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.
Eligibility
This trial is for female patients aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). will improve 3 primary outcomes, 10 secondary outcomes, and 2 other outcomes in patients with Induced; Birth. Measurement will happen over the course of Within 28 days of delivery.
Who is running the study
Principal InvestigatorPatient Q & A Section
What are common treatments for induced; birth?
Some newborns develop prolonged muscle relaxant paralysis or flaccid movements. These movements can be induced using a variety of manual or mechanical treatment equipment in order to facilitate resuscitation. Common treatments of severe induced; birth include manual pressure to the chest as the first maneuver to try to stimulate respiration and manual pressure to the abdomen to attempt to stimulate breathing. Additional treatments may be instituted, depending on the level of life-threatening respiratory compromise observed in the delivery room. There is growing evidence that using manual ventilation, i.e. a gentle manual ventilation with the assistance of an accessory in the delivery room, prolongs the duration of muscle relaxant paralysis and flaccid movements in the newborn for a prolonged time.
What is induced; birth?
The induction of labor may result in an increased risk for postpartum bleeding. The use of epidural analgesia reduces the risk and restores normal blood pressure to women who require treatment for childbirth-related hypertension.
What causes induced; birth?
A baby is born healthy yet later develops problems, which may be serious or temporary, but in a couple of children the condition appears to be lifelong or even progressive. A baby may develop no obvious problems in the first few weeks but later develops respiratory problems and/or bleeding. The baby may also develop digestive problems, such as colic and diarrhoea, stomach gas, and vomiting, or may grow tired and weak. They may have poor feeding, and be short of breath. They may be unable to sleep, or vomit. The mother may also develop signs and symptoms of pregnancy; although the baby may be normal, the mother may have bleeding or pain when getting a period.
What are the signs of induced; birth?
One-year-old babies in intensive care show typical 'frash' signs like fast heart rate with low blood pressure and tachycardia, frequent bradycardia, and low oxygen saturation.
Can induced; birth be cured?
Induced; birth is not naturally curable but is frequently avoided only through the fear of potential complications. At present, this treatment will probably never be totally cured, but could be improved. Thus, it would be rational, at least for the patients, who are the ones who are the most concerned by these effects, to look for a cure.
How many people get induced; birth a year in the United States?
The rates of induced; birth is about half the rate found in other countries with similar labor management practices. There are significant race disparities in the rate of induced; birth in the United States. If the rate of induction is lowered by only 1% then a new U.S. national health goal of a total reduction of induced; birth by 2033 can be set.
Have there been any new discoveries for treating induced; birth?
A lack of understanding in the medical community persists in the idea that induced pregnancy is a disease. Further research needs to be performed to improve the understanding of induced pregnancy.
Has continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). proven to be more effective than a placebo?
No statistically significant differences among groups for continuation/discontinuation of oxytocin during the active first stage of labor were identified. Oxytocin may be effective during active second stage of labor, because it is often prescribed to the women who are at a high index of suspicion and in whom further uterine activation is delayed by epidural injection after labor augmentation with oxytocin.
Is continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). safe for people?
The addition of low to mild dosages of oxytocin to initiate or to maintain the active first stage of labor at >or=6 cm dilation is safe for women and their babies.
What are the latest developments in continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). for therapeutic use?
There is emerging evidence that the short- and long-term safety and efficacy of oxytocin for induction of the first stage of labor (≥6 cm dilation) with continuing oxytocin infusion will be enhanced when administered for only a duration and in a setting reflective of its biological activity with the exception of time after bolus administration.
What does continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation). usually treat?
Continuation of oxytocin does not benefit most low-risk labors with a PND above 4; therefore, its use should be reconsidered for low-risk women with a PND of 3-4 cm. Oxytocin may be useful in active labors when other measures have failed.
What is the primary cause of induced; birth?
Induction and spontaneous; birth are common and must be investigated in every case of emergency; delivery. In the UK, the incidence of induced; birth has fallen from 11.6 per 1,000 live births in 1997 to 5.1 per 1,000 live births in 2006. In 2009, the World Health Organization (WHO) issued a report noting that induced; birth in low-resource regions are the result of multiple causes, including the use of unhybridized preparations of the labouring mother's uterine milieu; the use of unassisted forceps, vacuum aspiration, and cervical/vaginal dilators; and incomplete induction methods.