Neuroblastoma Clinical Trials

Neuroblastoma studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect neuroblastoma clinical trial.

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Washington, United States

Washington, United States

< 65

All Sexes

The is a phase II, single arm, open-label, multi-site trial studying the combination of cryoablation therapy and dual checkpoint inhibition with nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4) given at the recommended phase 2 dose (RP2D) in pediatric and young adult patients with relaps…

This study will expand the types of pediatric cancers being evaluated for response to cabozantinib. The current COG study is restricted to Ewing sarcoma, osteosarcoma, rhabdomyosarcoma, Wilms tumor, and a handful of uncommon tumors. The proposed study will extend this evaluation to tumors …

Bintrafusp alfa / M7824

This study is evaluating whether a drug can shrink or disappear ONB tumors.

This study is evaluating whether a drug called N9 is safe and effective for children with neuroblastoma.

This study is evaluating whether a combination of a vaccine, a sugar, and a protein can be effective in treating people with high-risk neuroblastoma.

This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or does not respond to treatment (refractory). Tegavivint interferes with the binding of beta-catenin to TBL1, whic…

Tumor-specific ex vivo expanded autologous lymphocyte transfer (TTRNA-xALT)

This study is evaluating whether a combination of treatments may help children with DIPG or recurrent neuroblastoma.

This study is evaluating whether a combination of two monoclonal antibodies can shrink or stabilize relapsed or refractory neuroblastoma or relapsed osteosarcoma.

This study is evaluating whether a combination of two drugs may help treat children and young adults with cancer.

This study is evaluating whether a PET scan can be used to confirm or exclude the presence of neuroblastoma.

This study is evaluating whether a PET scan can be used to help diagnose neuroendocrine tumors in children and adults.

Radiopharmaceutical 68Ga-DOTATATE

This study is evaluating whether a new imaging agent can be used to stage neuroblastoma.

GD2-CAR-expressing Autologous T-lymphocytes

This study is evaluating whether a new type of immune cell therapy called GD2CART is safe and effective in treating patients with osteosarcoma or neuroblastoma that has come back (relapsed) or does not respond to treatment (refractory).

Allogeneic Hematopoietic Stem Cell Transplantation

This study is evaluating whether a stem cell transplant may help treat cancer that has come back or does not respond to treatment.

This study is evaluating whether the combination of two immunotherapy drugs may help treat children and adolescents with cancer.

second generation 4-1BBζ B7H3-EGFRt-DHFR(selected) and a second generation 4-1BBζ CD19-Her2tG

This study is evaluating whether genetically modified T cells may be able to

This study is evaluating whether a combination of drugs may help treat high-risk neuroblastoma.

This study is evaluating whether a new drug may help treat children with cancer.

This study is evaluating whether a drug may help treat certain types of cancer.

Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective against tumors that have come back or that have not responded to standard therapy. The goals o…

This study is evaluating whether a drug called DFMO may help treat neuroblastoma.

This study is evaluating whether a drug called tipifarnib may help treat children with cancer.

This study is evaluating whether a drug called 9-ING-41 may help treat cancer in children.

This research clinical trial is studying the creation and administration of GVAX, an irradiated GM-CSF secreting, autologous neuroblastoma cell vaccine (GVAX) in combination with nivolumab and ipilimumab as a possible treatment for neuroblastoma. The names of the study drugs involved in t…

This study is evaluating whether a drug may help treat children with cancer.

This study is evaluating whether a drug may help treat neuroblastoma.

Gallium Ga 68-DOTATATE

This study is evaluating whether a new type of scan called a PET/CT scan can help diagnose neuroendocrine tumors in children.

This is a Phase I/II, multicenter, open-label, multi-arm study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of idasanutlin, administered as a single agent or in combination with chemotherapy or venetoclax, in pediatric and young adult participan…

This study is evaluating whether a radioactive substance may help treat neuroblastoma.

dabrafenib

Washington, United States

Washington, United States

Any Age

All Sexes

This study is evaluating whether a combination of two drugs may help children with cancer.

Humanized 3F8 Bispecific Antibody

This study is evaluating whether a new drug may be safe for individuals with cancer.

Eflornithine Hydrochloride

This study is evaluating whether a combination of chemotherapy, immunotherapy, and eflornithine might be more effective than chemotherapy alone in treating patients with relapsed or refractory neuroblastoma.

This study is evaluating the side effects and how well dinutuximab and sargramostim work with combination chemotherapy in patients with high-risk neuroblastoma undergoing stem cell transplant.

iC9.GD2.CAR.IL-15 T-cells

The body has different ways of fighting infections and disease. No single way seems perfect for fighting cancer. This research study combines two different ways of fighting disease: antibodies and T cells. Antibodies are molecules that fight infections and protect your body from diseases c…

This study is evaluating whether a drug may help children with cancer.

This study is evaluating whether ulixertinib is effective in treating children with solid tumors that have spread to other places in the body (advanced), non-Hodgkin lymphoma, or histiocytic disorders that have a genetic

This study is for patients with neuroblastoma, sarcoma, uveal melanoma, breast cancer, or another cancer that expresses a substance on the cancer cells called GD2. The cancer has either come back after treatment or did not respond to treatment. Because there is no standard treatment at thi…

second generation 4-1BBζ EGFR806-EGFRt and a second generation 4 1BBζ CD19-Her2tG

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's b…

This study is evaluating whether a radioactive substance may help treat neuroblastoma.

PET (positron emission tomography) scans combined with a radioactive tracer will be used to identify and analyze tumors. Currently, the most common tracer used to analyze neuroblastoma tumors is called 123I-mIBG. However, the picture it provides is not always clear enough to see the very s…

This study is evaluating whether a drug may help treat children with cancer.

This study is evaluating whether a drug called CLR 131 may help treat cancer.

Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease. Despite this terrible and frustrating outcome, continued treatment of this population remains fundamental to improving cure rates. Studying thi…

Children and adults diagnosed with high-risk neuroblastoma patients with primary refractory disease or incomplete response to salvage treatment in bone and/or bone marrow will be treated for up to 101 weeks with naxitamab and granulocyte-macrophage colony stimulating factor (GM-CSF). Patie…

This study is evaluating whether a combination of two therapies may be more effective than either therapy alone.

This research study combines two different ways of fighting cancer: antibodies and Natural Killer T cells (NKT). Antibodies are types of proteins that protect the body from infectious diseases and possibly cancer. T cells, also called T lymphocytes, are special white blood cells that can k…

This study is evaluating whether a drug may help treat cancer.

This study is evaluating whether olaparib may help treat children with cancer.

This study is evaluating whether a drug may help treat children with cancer.

Larotrectinib Sulfate

This study is evaluating whether a drug called larotrectinib may help treat children with cancer.

This study is evaluating whether selumetinib sulfate is effective in treating children with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with MAPK pathway activation mutations that have spread to other places in

This study is evaluating whether tazemetostat is effective in treating patients with brain tumors, solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that have come back (relapsed) or do not respond to

This study is evaluating whether a drug may help treat children with cancer.

This study is evaluating whether a drug called Hu3F8 can be given with chemotherapy drugs and another drug called GM-CSF.

This study is evaluating whether genetic testing may help doctors plan better treatment for patients with solid tumors or non-Hodgkin lymphomas.

Dexrazoxane Hydrochloride

This study is evaluating whether a combination of two drugs may be more effective than one drug alone in treating neuroblastoma.

This study is evaluating whether a drug may help treat neuroblastoma.

This study is evaluating whether a drug called Hu3F8 plus GM-CSF can prevent your neuroblastoma from growing.

Neuroblastoma, the most common extra-cranial solid tumour in children, remains one of the major challenges in paediatric oncology. A promising way to further improve outcome in this disease appears to be the development of adjuvant therapeutic strategies. In this research the anti-GD2 anti…

This study is evaluating whether a drug may help treat children with cancer.

The purpose of this research study is to match genomic aberrations in tumor cells at time of relapse to rationally designed combinations of molecularly targeted agents. This study will be done in two parts: Part I: Tumor will be accessed at study entry via a biopsy and subjected to deep s…

Difluoromethylornithine (DFMO)

This study is evaluating whether a drug may help prevent recurrence of neuroblastoma.

This study is evaluating whether it is safe and feasible to give the participant cyclophosphamide, natural killer cells, and an antibody called Hu3F8 as a treatment for neuroblastoma.

This study is evaluating whether a drug may help treat brain tumors.

Autologous Stem Cell Infusion

This study is evaluating whether a specific chemotherapy regimen may help improve survival for individuals with neuroblastoma.

This study is evaluating whether a combination of natural killer cells and chemotherapy may help treat children with neuroblastoma.

Magnetic resonance high intensity focused ultrasound

Washington, United States

Washington, United States

< 65

All Sexes

This study is evaluating whether a combination of a drug and a focused ultrasound may be effective for treating children with cancer.

This study is evaluating whether a transplant of white blood cells from a close relative may help leukemia patients recover following chemotherapy.

This study is evaluating whether a new investigational drug can prevent reoccurrence of neuroblastoma that is in remission.

Patient Derived CD171 specific CAR T cells expressing EGFRt (long spacer 2nd generation T cells)

This study is evaluating whether genetically modified T cells can help treat neuroblastoma.

This study is evaluating how an antibody called Hu3F8 travels through the body and to tumors.

Pharmacological Study

This study is evaluating whether a combination of nivolumab and ipilimumab is safe and effective in treating younger patients with solid tumors or sarcomas that have come back (recurrent) or do not respond to treatment (refractory).

External beam radiotherapy

This study is evaluating whether a lower dose of radiation will help reduce late side effects.

This study is evaluating whether a treatment plan based on tumor biology may help treat patients with neuroblastoma.

laboratory evaluations of immune responses

Previous research has demonstrated that investigators can coat (arm) T cells with a special molecule called GD2 bispecific antibody that will help T cells recognize neuroblastoma and osteosarcoma cells and kill them. This bispecific antibody recognizes GD2, a protein found on almost all ne…

This study is evaluating whether a new technology can be used to determine the molecular makeup of a tumor.

This study is evaluating whether a drug called DFMO can be used to treat neuroblastoma.

Proton Beam Radiation Therapy

This research study is evaluating a therapy called proton beam radiation therapy (PBRT) as a possible treatment for neuroblastoma. Neuroblastoma most commonly occurs in and around the adrenal glands, which are located at the top of the kidneys. However, it can also occur in other areas wh…

Donor NK Cell Infusion

This study is evaluating whether a cellular and adoptive immunotherapy approach can improve disease control rate for people with cancer.

Magnetic Resonance High Intensity Focused Ultrasound

Washington, United States

Washington, United States

< 65

All Sexes

This study is evaluating whether a new type of surgery may be effective for treating tumors in children and young adults.

This study is evaluating whether a drug called DFMO can be used with celecoxib, cyclophosphamide and topotecan to treat cancer.

MM-398 (Irinotecan Sucrosofate Liposome Injection) plus cyclophosphamide

This study is evaluating whether a combination of two drugs may help treat certain types of cancer.

This study is evaluating whether a new gene can be put into T cells that will make them recognize and kill sarcoma and neuroblastoma cells.

This study is evaluating whether a new antibody can improve the outcome of children with high-risk neuroblastoma.

hematopoietic stem cell infusion

This study is evaluating whether a radioactive substance may help treat neuroblastoma.

This study is evaluating whether a combination of chemotherapy and a gene therapy can improve the survival of patients with relapsed/refractory neuroblastoma.

Guided Therapy- Pediatric Gene Analysis Platform

This study is evaluating whether a new technology can be used to determine a tumor's molecular makeup and mutations.

pharmacological study

This study is evaluating whether a stem cell transplant can be used to treat neuroblastoma.

This study is evaluating whether a combination of chemotherapy drugs and monoclonal antibodies is more effective than chemotherapy drugs alone in treating younger patients with neuroblastoma.

This study is evaluating whether a drug called Hu3F8 combined with GM-CSF is safe for treating neuroblastoma.

This study is evaluating the side effects and best dose of lenalidomide when given together with dinutuximab with or without isotretinoin in treating younger patients with neuroblastoma that does not respond to treatment or that has come back

The purpose of this research study is to evaluate a new investigational drug to prevent reoccurrence of neuroblastoma that is in remission. This study drug is called DFMO. The objectives of this study will be to monitor for safety and look at efficacy of DFMO. The safety of the proposed d…

Humanized 3F8 Monoclonal Antibody (Hu3F8)

This study is evaluating whether Hu3F8 is safe for treating neuroblastoma and other cancers.

FLT-PET

Detroit, MI