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GPC2 CAR T Cells for Neuroblastoma (GPC2 Trial)
GPC2 Trial Summary
This trial tests a new cancer treatment to see if it's safe for people with an advanced form of childhood cancer.
GPC2 Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.GPC2 Trial Design
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Who is running the clinical trial?
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- My neuroblastoma has come back or hasn't gone away after treatment.I have active hepatitis B or C.I have not received any live vaccines in the last 30 days.My organs are working well.My child's neuroblastoma is classified as high-risk.I am at least 1 year old.I do not have any uncontrolled infections.I do not have severe heart issues like recent heart attacks or uncontrolled heart rhythm problems.I have a condition that weakens my immune system.I am not on steroids or immunosuppressants that could affect cell therapy, except for certain allowed cases.I can do most activities but may need help.My cancer has spread to my brain and is getting worse.
- Group 1: Dose Expansion Arm
- Group 2: Dose Escalation Arm
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the overall aim of this research endeavor?
"This five-year research endeavour aims to ascertain the optimal dosage of GPC2 CAR T cells. Secondary objectives are evaluating manufacturing feasibility, persisting presence of said cells via PCR and/or flow cytometry testing, and preliminarily assessing the clinical efficacy for patients with relapsed or resistant neuroblastoma through international response criteria assessment."
Has the Dose Expansion Arm been given permission to be employed by the FDA?
"The safety of Dose Expansion Arm was estimated to be a 1 due to the Phase 1 trial status, indicative of limited data regarding its efficacy and security."
What is the current number of participants in this research project?
"Confirmed, the data found on clinicaltrials.gov indicates that recruitment for this investigation is in progress. This medical trial was originally uploaded to the platform on May 23rd 2023 and has been recently updated with information regarding its needs: 30 patients from 1 separate clinical centre."
Does this investigation have any open slots for participation?
"According to the data presented on clinicaltrials.gov, this research endeavour is actively seeking viable candidates. This trial was first announced on May 23rd 2023 and most recently updated on that same day."
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