Norepinephrine vs Vasopressin for Heart Surgery Patients
What You Need to Know Before You Apply
What is the purpose of this trial?
The relative increase in the mPAP with the same unit increase in MAP adjusted for baseline, and RV function assessed by GLS, between VP and NE in patients with normal and increased pulmonary artery pressure, who require vasopressor support during cardiac surgery.
Who Is on the Research Team?
Mariya Geube, MD
Principal Investigator
The Cleveland Clinic
Are You a Good Fit for This Trial?
This trial is for adults over 18 who are having elective heart surgery with a device called CPB and need a pulmonary artery catheter. They must have low blood pressure during surgery needing drugs to raise it. It's not for those getting transplants, certain implants, specific lung surgeries, or using inhaled lung medicines before the study starts.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Intraoperative Treatment
Participants receive vasopressor support with either vasopressin or norepinephrine during cardiac surgery
Immediate Postoperative Monitoring
Monitoring of mPAP-to-MAP ratio and RV function using transesophageal echocardiography
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Norepinephrine
- Vasopressin
Norepinephrine is already approved in United States, Canada, European Union for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Cleveland Clinic
Lead Sponsor