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Insulin Clamp for Organ Transplant Complications

N/A

Waitlist Available

Led By Dr. Peter Metrakos, MD

Research Sponsored by McGill University Health Centre/Research Institute of the McGill University Health Centre

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Donors must be over 18 years of age

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 year post-transplant

Awards & highlights

Study Summary

This trial will test the effects of the glucose/insulin clamp on cadaveric organ donors.

Who is the study for?

This trial is for cadaveric organ donors over 18 years old who have been declared brain dead. It's not for those with uncontrolled high blood sugar, diagnosed with Type 1 Diabetes, or if organs aren't retrieved for transplant. Consent must be obtained under Transplant Quebec regulations.Check my eligibility

What is being tested?

The study tests a glucose/insulin clamp technique on deceased donors to prevent high blood sugar and reduce inflammation before organ retrieval. The goal is to improve the survival and function of transplanted hearts, livers, kidneys, and pancreases after one year.See study design

What are the potential side effects?

Since this intervention involves deceased donors rather than living patients, traditional side effects are not applicable in the same way as they would be for interventions given to live subjects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am over 18 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 year post-transplant

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 year post-transplant

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year post-transplant for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

• Drop in the inflammatory cytokine response after brain death after a minimum of 6 hours therapy with the GICT prior to organ procurement.

Secondary outcome measures

Assess organ (heart, liver, pancreas and kidney) survival at one year post-transplant

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Glucose/Insulin ClampExperimental Treatment1 Intervention

Group II: ControlActive Control1 Intervention

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

McGill University Health Centre/Research Institute of the McGill University Health CentreLead Sponsor

442 Previous Clinical Trials

159,154 Total Patients Enrolled

Dr. Peter Metrakos, MDPrincipal InvestigatorMcGill University Health Centre/Research Institute of the McGill University Health Centre

Media Library

Glucose/Insulin Clamp (Other) Clinical Trial Eligibility Overview. Trial Name: NCT01304290 — N/A

Complication of Organ Transplant Research Study Groups: Control, Glucose/Insulin Clamp

Complication of Organ Transplant Clinical Trial 2023: Glucose/Insulin Clamp Highlights & Side Effects. Trial Name: NCT01304290 — N/A

Glucose/Insulin Clamp (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01304290 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it possible to enlist in this clinical trial?

"This clinical investigation is seeking 20 individuals, aged between 18 and 75, who have experienced a complication due to an organ transplant. The donor must be over the age of consent as well as meeting additional criteria such as only accepting brain death donations with prior approval from Transplant Quebec."

Answered by AI

Are there any remaining positions available for participants in this clinical investigation?

"Per clinicaltrials.gov, this study is presently not recruiting any new patients. Initially posted on October 1st 2010 and most recently updated three years later, it does not currently have an open call for participants; however, there are other medical trials actively enrolling right now."

Answered by AI