Browse 14 Bydureon Medical Studies Across 18 Cities
4 Phase 3 Trial · 24 Bydureon Clinics
What Are Bydureon Clinical Trials?
Bydureon BCise is the brand name of a prolonged-release non-insulin medication, exenatide, designed to control blood sugar levels and keep them consistent. Bydureon treats type 2 diabetes mellitus, not type 1 diabetes.
This pre-filled, single-use injection pen medication is prescribed, in combination with diet and exercise, for adults, adolescents, and children ten years or older with type 2 diabetes that is inadequately controlled with just oral medications.
Bydureon clinical trials study the efficacy of Bydureon BCise for diseases that affect glucagon-like peptide-1 (GLP-1) receptors. This medication is approved for type 2 diabetes treatment but is also being evaluated for neurodegenerative disorders.
Why Is Bydureon BCise Being Studied In Clinical Trials?
Bydureon BCise is being studied to compare its effects in different patient populations and in combination with other drug or non-drug treatments. Researchers are testing the reduction of HbA1c (A1C) levels in clinical trial patients, especially patients ages 10-17.
Additional trials are exploring the efficacy of exenatide for Parkinson’s and Alzheimer’s Disease. GLP-1 receptors have been found in the brain, and studies are examining the neuroprotective effects of GLP-1 receptor agonists in neurodegenerative disorders.
How Does Bydureon BCise Treatment Work?
Bydureon BCise uses an extended-release delivery system that works by stimulating GLP-1 receptors in the pancreas. It stimulates the pancreas to secrete insulin when blood sugar levels are high. It also slows gastric emptying from the stomach to send sugar into the bloodstream measuredly (see section 12 - Clinical Pharmacology).
Patients can self-inject this medication subcutaneously every seven days.
What Are Some of the Breakthrough Clinical Trials Involving Bydureon BCise?
Several recent studies have evaluated Bydureon BCise. Some of the most impactful studies are:
2017: Long-Term Efficacy for Type 2 Diabetes – This research evaluated studies and found that after 15 weeks of therapy, 2mg of exenatide achieved better glycemic control compared to a placebo and a lower dose of 0.8mg a week.
2020: Parkinson’s Disease – This research evaluated studies that compared GLP-1 receptor agonists with conventional Parkinson’s Disease (PD) treatment, placebo, or no treatment. The research found that exenatide may improve motor impairment for people with PD, though results have not been confirmed with high certainty.
2021: Adolescent Patients with Type 2 Diabetes – This study gave pediatric patients exenatide once weekly (EQW) as both monotherapy and adjunctive therapy to oral antidiabetic agents and insulin. The study found that exenatide extended-release significantly improved glycemic control compared to a placebo.
Who Are The Key Opinion Leaders On Bydureon Clinical Trial Research?
William Tamborlane, MD, is a professor of Pediatric Endocrinology at Yale University. He has conducted many studies on pediatric diabetes, including pioneering studies developing insulin pump therapy.
Stefano Genovese is the Director of the Diabetes, Endocrinology, and Metabolic Diseases unit at the Centro Cardiologico Monzino (IRCCS). He is an Italian researcher who has conducted significant research in medical fields surrounding diabetes. Genovese has studied diabetes and metabolism since 1991.
Dr. Richard Wyse is Director of Clinical Development at The Cure Parkinson’s Trust (CPT), a prominent research body for Parkinson’s Disease. He created the International Linked Clinical Trials programme (iLCT), which operates in the UK, US, Australia, and Europe.