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Anti-inflammatory Agent

Minocycline for Stress and Motivation (BASS Trial)

Phase 4

Waitlist Available

Led By Keely Muscatell, PhD

Research Sponsored by University of North Carolina, Chapel Hill

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up within approximately 24 hours after the final dose; day 6 minocycline to day 6 placebo

Awards & highlights

BASS Trial Summary

This trial examines the effects of anti-inflammatory drugs on reward-related motivation of unemployed people under chronic stress. It hopes to identify new treatments for psychiatric disorders.

Eligible Conditions

Stress
Motivation

BASS Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ within approximately 24 hours after the final dose; day 6 minocycline to day 6 placebo

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~within approximately 24 hours after the final dose; day 6 minocycline to day 6 placebo

This trial's timeline: 3 weeks for screening, Varies for treatment, and within approximately 24 hours after the final dose; day 6 minocycline to day 6 placebo for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in response bias during the Probabilistic Reward Task

Secondary outcome measures

Change in Motivation and Pleasure Scale (MAPS) score

Change in Snaith Hamilton Pleasure Scale score

BASS Trial Design

2Treatment groups

Experimental Treatment

Group I: Placebo followed by MinocyclineExperimental Treatment2 Interventions

In this arm, participants will take a 5-day course of placebo-control pills and then a 5-day course of 200 mg of minocycline. Sessions will be separated by a minimum washout period of 14 days.

Group II: Minocycline followed by PlaceboExperimental Treatment2 Interventions

In this arm, participants will take a 5-day course of 200 mg of minocycline and then a 5-day course of placebo-control pills. Sessions will be separated by a minimum washout period of 14 days.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Minocycline

2005

Completed Phase 4

~1000

Placebo

1995

Completed Phase 3

~2670

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of North Carolina, Chapel HillLead Sponsor

1,506 Previous Clinical Trials

4,190,543 Total Patients Enrolled

Robert Wood Johnson FoundationOTHER

157 Previous Clinical Trials

686,816 Total Patients Enrolled

Gabriella Alvarez, PhDStudy DirectorUniversity of North Carolina, Chapel Hill

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

May I join this research endeavor?

"The ideal candidate for this research has a medical history of stress and is between 25 to 50 years old. At the moment, there are 38 open slots in the trial."

Answered by AI

Is the age limit for participants of this experiment above fifty-five years old?

"This medical trial is restricted to those aged between 25 and 50. Alternatively, there are 19 trials for younger individuals and 70 studies available for older patients."

Answered by AI

Has Minocycline obtained authorization from the FDA?

"Data collected during the Phase 4 trials of minocycline indicates that it is safe, therefore earning a score of 3."

Answered by AI

What is the current number of participants in this medical experiment?

"Indeed, the information hosted on clinicaltrials.gov confirms that this medical study is currently recruiting patients. The trial was posted in September of 2022 and most recently refreshed on 12th September 2023. 38 participants are needed to be recruited from a single location."

Answered by AI

Are new participants being accepted for the trial at this time?

"Affirmative. According to clinicaltrials.gov, this experiment is recruiting participants now and was initially posted on September 12th 2022; its last listing update took place a year later on the same date. The study requires 38 individuals at one medical centre."

Answered by AI

Recent research and studies

Comprehensive PsychiatryJournal

The Motivation and Pleasure Scale–self-report (MAP-SR): Reliability and Validity of a Self-report Measure of Negative Symptoms

Llerena, Katiah, Stephanie G. Park, Julie M. McCarthy, Shannon M. Couture, Melanie E. Bennett, and Jack J. Blanchard. 2013. “The Motivation and Pleasure Scale–self-report (MAP-SR): Reliability and Validity of a Self-report Measure of Negative Symptoms”. Comprehensive Psychiatry. Elsevier BV. doi:10.1016/j.comppsych.2012.12.001.

clinicaltrials.govStudy

Brain and Stress Study

2022. "Brain and Stress Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06044090.