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Positive Processes and Transition to Health (PATH) for Post-Traumatic Stress Disorder (PATH Trial)

N/A
Waitlist Available
Led By Norah C Feeny, PhD
Research Sponsored by Case Western Reserve University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline score at 6 weeks (immediately post treatment)
Awards & highlights

PATH Trial Summary

This trial will test a new therapy called Positive Processes and Transition to Health (PATH) to see if it helps people with symptoms of PTSD and/or depression. PATH will be given to 45 adults who have experienced a major life event, like the loss of a loved one. The goals of this trial are to see if PATH works and if patients stick with the therapy.

Eligible Conditions
  • Post-Traumatic Stress Disorder
  • Depression

PATH Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline score at 6 weeks (immediately post treatment)
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline score at 6 weeks (immediately post treatment) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Affective Updating Task (Pe et al., 2013; Pe, Raes, et al., 2013)
Idiographic Behavioral Approach Task
Probabilistic Reward Task (Pizzagalli et al., 2005)
Secondary outcome measures
Mental Depression
Posttraumatic Cognitions Inventory (Foa et al., 1999)
Snaith-Hamilton Pleasure Scale (Snaith et al., 1995)

PATH Trial Design

1Treatment groups
Experimental Treatment
Group I: receive PATH therapyExperimental Treatment1 Intervention
PATH includes six 60-90 min, weekly sessions, with two booster sessions for partial responders. Session 1 provides the PATH rationale and a review of life events (PATH of life: negative and positive). A rationale for an explicit focus on positive events/emotions will be provided. Sessions 2-4 focus on a verbal narrative of the destabilizing life event, reminiscence and processing of a major positive life event, and real-life practice to enact what was taught. Sessions 5 focuses on constructive processing and provides opportunity for integration and consolidation of learning. Session 6 focuses on future negative and positive events to promote application of new learning and resilience. Booster sessions focus on positive and negative life events since the last session and adaptive processes (constructive processing, approach, and reward). All sessions will include cultivation and elaboration of positive emotions to promote engagement and to build on the benefits of positive emotions.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Positive Processes and Transition to Health (PATH)
2021
N/A
~50

Find a Location

Who is running the clinical trial?

University of WashingtonOTHER
1,738 Previous Clinical Trials
1,844,306 Total Patients Enrolled
Case Western Reserve UniversityLead Sponsor
299 Previous Clinical Trials
259,975 Total Patients Enrolled
University of DelawareOTHER
154 Previous Clinical Trials
25,166 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the age limit for this medical trial extend beyond eighty-five years old?

"Adhering to this trial's enrollment requirements, the age cut-off is 18 years old as a minimum and 65 as a maximum."

Answered by AI

Am I eligible to enroll in this investigatory project?

"To be eligible for consideration, applicants must have a history of stress disorders or trauma and meet the age requirement of 18 to 65. A total of 45 people will be accepted into this clinical trial."

Answered by AI

Is it possible to participate in this experiment at the moment?

"Affirmative. According to clinicaltrials.gov, this medical experiment commenced on April 1st 2022 and was revised most recently on April 28th of the same year. 45 participants must be enlisted from 3 distinct clinics in order for the trial to move forward."

Answered by AI

How many participants are currently enrolled in this scientific experiment?

"To move this study forward, 45 qualified participants will be required. Those who wish to join can do so through University of Washington in Seattle or the University of Delaware in Newark."

Answered by AI

Who else is applying?

What state do they live in?
Washington
Ohio
What site did they apply to?
Case Western Reserve University
University of Washington
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I’ve tried many different types of medications/treatments for depression and most haven’t worked. The idea of being paid to hopefully help other people to get better treatment makes me hopeful for people’s mental health and my own.
PatientReceived 1 prior treatment

What questions have other patients asked about this trial?

Is this trial paid in any way?
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
Positive Processes and Transition to Health
Norah Feeny 2021. "Positive Processes and Transition to Health". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04678232.
~13 spots leftby Apr 2025
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