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Limonene Metabolism and CYP2C19 Genetic Variants
N/A
Recruiting
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age range: Greater than 18 years and less than 45 years
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 hours
Awards & highlights
Study Summary
This trial will test whether a non-invasive screening tool for a certain gene can be developed by measuring how the body metabolizes a certain substance.
Who is the study for?
This trial is for men and women of East Asian ethnicity, aged between 18 and 45 years. It aims to find out if a simple test can be made to check genetic differences affecting how the body handles certain substances.Check my eligibility
What is being tested?
The study is testing whether limonene, a common substance found in citrus oils, can help develop a non-invasive tool to screen for genetic variants that affect drug metabolism.See study design
What are the potential side effects?
Since this trial involves measuring metabolism rather than treating disease, side effects are not the main focus. However, any potential mild reactions from exposure to limonene will be monitored.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 19 and 44 years old.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 2 hours
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 hours
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Breath limonene value in parts per billion
Trial Design
2Treatment groups
Experimental Treatment
Group I: Wildtype CYP2C19Experimental Treatment1 Intervention
The group of participants has been genotyped to have wild-type CYP2C19. The participants will consume 1 oz water mixed with 500mg limonene (Jarrow Formula orange peel extract) and be asked to swish 5 times and swallow. All participants will then provide breath samples over the course of 2 hours. The breath sample outcomes will be compared to those of the CYP2C19*2 and/or CYP2C19*3 study subjects.
Group II: CYP2C19*2 and CYP2C19*3 VariantsExperimental Treatment1 Intervention
The group of participants has been genotyped to have the CYP2C19*2 and/or CYP2C19*3 variant during the first part of the study. The participants will consume 1 oz water mixed with 500mg limonene (Jarrow Formula orange peel extract) and be asked to swish 5 times and swallow. All participants will then provide breath samples over the course of 2 hours. The breath sample outcomes will be compared to those of the wild-type CYP2C19 study subjects.
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Who is running the clinical trial?
Stanford UniversityLead Sponsor
2,394 Previous Clinical Trials
17,341,590 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am either male or female.I have a history of stroke or heart disease.I am either younger than 18 or older than 45.I have experienced chest pain or shortness of breath in the last month.I am between 19 and 44 years old.I am not taking any medications that affect CYP2C19 enzyme activity.
Research Study Groups:
This trial has the following groups:- Group 1: Wildtype CYP2C19
- Group 2: CYP2C19*2 and CYP2C19*3 Variants
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are adults aged 25 and above eligible participants for this research trial?
"This clinical study has an age requirement of 18-45 years old, as mandated by the set inclusion criteria."
Answered by AI
What is the peak capacity of people involved in this medical experiment?
"Affirmative. The clinical trial's information available onclinicaltrials.gov suggests that recruitment is still in progress, with the initial post being published October 30th 2021 and a recent update made August 18th 2022. At present, 20 participants have to be recruited from 1 site."
Answered by AI
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