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Tetracycline Antibiotic

Minocycline 100mg for Multiple Sclerosis (MS Trial)

Phase 3
Waitlist Available
Led By Luanne Metz, MD,FRCPC
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3,6,12,and 24 months
Awards & highlights

MS Trial Summary

This trial is testing a possible treatment for people who have had a recent demyelinating event, which is a type of damage to the nervous system. The treatment is a drug called minocycline, which will be given until the endpoint is reached (24 months).

Eligible Conditions
  • Multiple Sclerosis
  • Clinically Isolated Syndrome

MS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3,6,12,and 24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3,6,12,and 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
proportion of participants diagnosed with multiple sclerosis according to the 2005 McDonald Criteria
Secondary outcome measures
Proportion of participants diagnosed with multiple sclerosis according to the 2005 McDonald Criteria
The proportion of participants with no evidence of disease activity (NEDA)

MS Trial Design

1Treatment groups
Experimental Treatment
Group I: MinocyclineExperimental Treatment1 Intervention
Minocycline 100 mg oral twice daily for up to 24 month
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Minocycline
FDA approved

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
791 Previous Clinical Trials
868,725 Total Patients Enrolled
9 Trials studying Multiple Sclerosis
407 Patients Enrolled for Multiple Sclerosis
Multiple Sclerosis Society of CanadaOTHER
14 Previous Clinical Trials
992 Total Patients Enrolled
14 Trials studying Multiple Sclerosis
992 Patients Enrolled for Multiple Sclerosis
Hotchkiss Brain Institute, University of CalgaryOTHER
11 Previous Clinical Trials
2,423 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of patient would this research be appropriate for?

"This study is focusing on 148 patients with multiple sclerosis that are between 18-60 years old."

Answered by AI

To what extent does Minocycline 100mg put people at risk?

"There is some data supporting Minocycline 100mg's efficacy and safety, as this medication has been trialed in Phase 3 studies."

Answered by AI

Are there other scientific papers that mention Minocycline 100mg?

"There are a total of 21 clinical trials that are still ongoing for Minocycline 100mg. Out of these, 6 have progressed to Phase 3 testing. Most of the research is being conducted in Guangzhou, Guangdong; however, there are 37 different locations running trials for Minocycline 100mg."

Answered by AI

What are the primary benefits of taking Minocycline 100mg?

"Minocycline 100mg is a popular choice for treating rocky mountain spotted fever. This medication can also be helpful in managing q fever, dental root planing, and respiratory tract infections."

Answered by AI

Does this research allow for patients who are not yet 50 years old?

"To be eligible for this clinical trial, patients must between 18-60 years old. If the patient falls outside of this age range, there are other trials that may be more appropriate; 47 for those under 18 and 421 for seniors 65 and older."

Answered by AI

Are new participants still being accepted for this clinical trial?

"That is correct. As the information available on clinicaltrials.gov indicates, this study is still looking for 148 individuals to participate across 1 centre. The posting went up on 1/31/2020 and was last updated 2/27/2020."

Answered by AI

How many people are taking part in this experiment at most?

"Yes, the trial is still open to recruitment and was last updated 27th February of this year. The original posting date was the 31st of January in 2020. Currently, they are 148 participants needed at a single site."

Answered by AI

Who else is applying?

What state do they live in?
Pennsylvania
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
Recent research and studies
clinicaltrials.govStudy
Minocycline in MS: Confirmation of Benefit
Dr. Luanne Metz 2020. "Minocycline in MS: Confirmation of Benefit". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04291456.
~2 spots leftby Apr 2025
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