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Lovenox + Aspirin for Infertility

Phase 4
Recruiting
Led By Bruce Shapiro, MD, PhD
Research Sponsored by Fertility Center of Las Vegas
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Female patient 18-42 years of age with frozen embryos or oocytes seeking embryo transfer
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 days post transfer
Awards & highlights

Study Summary

This trial will compare patients taking aspirin and heparin to those without to see if it improves results.

Who is the study for?
This trial is for women aged 18-42 who want to have a frozen embryo transfer, including those using donated embryos or eggs. It's open to patients with any history of IVF cycles. Women must not be currently pregnant, under 18, unable to consent in English, using a surrogate, or have certain medical conditions like bleeding disorders.Check my eligibility
What is being tested?
The study is testing if Lovenox (a low-molecular weight heparin) combined with Aspirin can improve the success rates of thawed blastocyst transfers compared to standard protocols without these medications. Participants will be randomly assigned to either receive both drugs or none before their embryo transfer.See study design
What are the potential side effects?
Possible side effects from Lovenox and Aspirin may include bleeding issues due to thinner blood, allergic reactions, and irritation at the injection site for Lovenox. The severity of side effects can vary among individuals.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am a woman aged 18-42 with frozen embryos or eggs, seeking embryo transfer.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 days post transfer
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 days post transfer for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Serum hCG level

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Treatment ArmExperimental Treatment3 Interventions
Patients randomized to receive aspirin and Lovenox will begin taking one "low dose" 81mg aspirin and one 40mg injection of Lovenox daily, on the day of progesterone start.
Group II: Control ArmActive Control1 Intervention
This arm receives neither medication.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Embryo transfer
2017
Completed Phase 4
~2310
Lovenox
2012
Completed Phase 1
~180
Aspirin
2014
Completed Phase 4
~55580

Find a Location

Who is running the clinical trial?

Fertility Center of Las VegasLead Sponsor
5 Previous Clinical Trials
420 Total Patients Enrolled
Bruce Shapiro, MD, PhDPrincipal InvestigatorFertility Center of Las Vegas
2 Previous Clinical Trials
40 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it possible for individuals under the age of 45 to participate in this scientific exploration?

"Eligible participants for this research must be between the ages of 18 and 42."

Answered by AI

What evidence exists to suggest that Treatment Arm is secure for people?

"Due to its Phase 4 status, Treatment Arm was rated a 3 in terms of safety by our team at Power given that the treatment is already approved."

Answered by AI

Is this experiment recruiting volunteers at the present?

"Clinicaltrials.gov informs us that this medical trial is currently not enlisting any patients. This study, which was initially publicized on November 15th 2023 and updated most recently the same day, is at present not recruiting individuals; however there are 267 other trials presently open for enrollment."

Answered by AI

Do I meet the criteria to participate in this research?

"To be accepted into this clinical trial, participants ought to possess female infertility and must between 18-42 years of age. The study is looking to recruit approximately 130 individuals."

Answered by AI

Who else is applying?

What site did they apply to?
Fertility center of Las Vegas
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Lovenox With Aspirin in Thawed Blastocyst Transfer
2024. "Lovenox With Aspirin in Thawed Blastocyst Transfer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06133803.
All > Paid Studies Las Vegas > Durlaza
~87 spots leftby Dec 2024
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