Trigger Timing in Controlled Ovarian Stimulation for Female Infertility
What You Need to Know Before You Apply
What is the purpose of this trial?
This randomized trial will compare the efficacy of two different times of administration of medications for final oocyte maturation, commonly called a "trigger", in cycles of controlled ovarian stimulation (COS) for cycles in which all embryos will be cryopreserved ("freeze-all cycles").
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.
Is the timing of ovulation triggers in controlled ovarian stimulation safe for humans?
The use of human chorionic gonadotropin (hCG) for triggering ovulation can lead to ovarian hyperstimulation syndrome (OHSS), a potential risk. However, using a gonadotropin-releasing hormone agonist (GnRH-a) instead of hCG can reduce this risk, making it a safer option for ovulation triggering.12345
How is the ovulatory trigger timing treatment different from other treatments for female infertility?
The ovulatory trigger timing treatment using hCG (human chorionic gonadotropin) is unique because it mimics the natural LH (luteinizing hormone) surge to induce ovulation, but it may not optimally support the early luteal phase compared to natural cycles. This treatment is different from others as it can lead to faster and higher hormone levels than naturally observed, potentially affecting implantation success.678910
What data supports the effectiveness of the treatment for ovulatory trigger timing in controlled ovarian stimulation for female infertility?
Research suggests that using a combination of triggers, like hCG and GnRH agonist, can improve the number and quality of mature eggs and embryos in women undergoing fertility treatments. This approach, known as a 'dual trigger', has shown promise in improving pregnancy outcomes, especially in women who have a high rate of immature eggs.3671112
Are You a Good Fit for This Trial?
This trial is for adult women aged 18-35 with normal ovarian response, who are undergoing IVF and plan to freeze all embryos reaching the blastocyst stage. They must understand English to consent and can have had previous IVF cycles but only one cycle under this study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo controlled ovarian stimulation with early or delayed trigger timing for final oocyte maturation
Follow-up
Participants are monitored for the formation of good-quality blastocysts within 7 days of oocyte retrieval
What Are the Treatments Tested in This Trial?
Interventions
- Ovulatory trigger timing
Ovulatory trigger timing is already approved in European Union, United States, Canada for the following indications:
- Assisted reproductive technology (ART)
- Infertility treatment
- Infertility treatment
- Ovulation induction
- Assisted reproductive technology (ART)
- Infertility treatment
- Assisted reproductive technology (ART)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Fertility Center of Las Vegas
Lead Sponsor