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dHACM (AmnioWrap) for Incisional Hernia (NO-HERNIA Trial)

Phase 4
Waitlist Available
Research Sponsored by Louisiana State University Health Sciences Center in New Orleans
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

NO-HERNIA Trial Summary

This trial will compare the development of incisional hernias in patients who have dHACM added to their standard abdominal closure vs. those who only have a standard abdominal closure.

Eligible Conditions
  • Incisional Hernia

NO-HERNIA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence of IH as determined by physical exam or abdominal ultrasound demonstrating a midline fascial defect and hernia sac> 4mm diameter
Secondary outcome measures
Intraoperative and postoperative complications

NO-HERNIA Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Treatment Arm-dHACMExperimental Treatment1 Intervention
Patients enrolled in this arm will have a thin sheet of dHACM placed as an overlay over the length of the closed incisions. dHACM is Dehydrated Human Amniotic-Chorion Membrane. It is a FDA registered healing adjunct that has been applied in a broad range of diseases including wounds, plantar fasciitis and burns.
Group II: Control ArmActive Control1 Intervention
Patients enrolled in this arm will have routine closure.

Find a Location

Who is running the clinical trial?

LSUHSC-NOUNKNOWN
Louisiana State University Health Sciences Center in New OrleansLead Sponsor
114 Previous Clinical Trials
43,668 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Prospective, Double-Blinded, Randomized Controlled Trial of dHACM for Incisional Hernia Prophylaxis
Frank Lau, MD 2020. "A Prospective, Double-Blinded, Randomized Controlled Trial of dHACM for Incisional Hernia Prophylaxis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04417140.
All > Hernia
~108 spots leftby Apr 2025
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