Microwave Ablation for Liver Cancer
(ACCLAIM Trial)
Trial Summary
What is the purpose of this trial?
To demonstrate that microwave ablation (MWA) of up to 3 hepatic metastases, each with a maximum diameter of ≤ 2.5 cm will result in a 2-year local progression free survival of at least 90%. This is a standard of care (SOC) study.
Do I need to stop my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.
What data supports the effectiveness of the treatment Microwave Ablation for Liver Cancer?
Is microwave ablation safe for treating liver cancer?
What makes microwave ablation a unique treatment for liver cancer?
Microwave ablation (MWA) is unique because it uses microwave energy to create heat that destroys liver tumors, and it can create larger and more uniform areas of treatment compared to radiofrequency ablation (RFA), which is another common method. This makes MWA potentially more effective in treating larger tumors or those in difficult-to-reach areas.12347
Research Team
Constantinos Sofocleous, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Eligibility Criteria
This trial is for adults with colorectal cancer that has spread to the liver, with up to 3 small liver tumors (each ≤2.5 cm). Participants can have a few small lung lesions or lymph nodes and must be in good physical condition (ECOG 0-1). They should not have severe illnesses, uncontrolled bleeding disorders, allergies to IV iodine that can't be managed, active infections, or be pregnant.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo microwave ablation (MWA) of 1-3 colorectal cancer metastases with margin confirmation
Follow-up
Participants are monitored for local tumor progression and hepatic disease-free survival
Margin Assessment
Assessment of the ablation margin is conducted within 7 days post-MWA and again within 4-8 weeks
Treatment Details
Interventions
- Microwave Ablation
Microwave Ablation is already approved in United States, European Union for the following indications:
- Colorectal cancer liver metastases
- Unresectable liver lesions
- Small solitary lesions
- Colorectal cancer liver metastases
- Unresectable liver lesions
- Small solitary lesions
Find a Clinic Near You
Who Is Running the Clinical Trial?
Society of Interventional Oncology
Lead Sponsor