Microwave ablation with margin confirmation for Colorectal Liver Metastases

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Mayo Clinic, Rochester, MNColorectal Liver Metastases+1 MoreMicrowave ablation - Device
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trialtests if a procedure (MWA) can safely treat up to 3 small liver tumors with a good chance of long-term success.

Eligible Conditions
  • Colorectal Liver Metastases
  • Colorectal Liver Cancer

Treatment Effectiveness

Effectiveness Progress

1 of 3

Similar Trials

1
IRE ablation and radiation therapy
1
Axitinib 5 MG
1
Radiation Therapy

Study Objectives

1 Primary · 6 Secondary · Reporting Duration: 24 Months

24 Months
Hepatic progression free survival by Kaplan-Meier estimate
Local tumor progression free survival at 24 months
Local tumor progression free survival between sufficient (5.0-9.9 mm) and ideal (≥10 mm) ablation margin categories using Kaplan-Meier methodology and the log-rank test
Overall and disease specific survival following MWA using Kaplan-Meier methodology
Progression free survival using Kaplan-Meier methodology and the log-rank test
Proportion of target tumors treated with an ablation zone (AZ) that completely covers the target tumor(s) with minimal margin (MM) of at least 5 mm
90 Days
Proportion of subjects with CTCAE grade 3 events or greater within 90 days after MWA

Trial Safety

Safety Progress

1 of 3

Similar Trials

1
IRE ablation and radiation therapy
1
Axitinib 5 MG
1
Radiation Therapy

Trial Design

1 Treatment Group

Microwave ablation with margin confirmation
1 of 1

Experimental Treatment

275 Total Participants · 1 Treatment Group

Primary Treatment: Microwave ablation with margin confirmation · No Placebo Group · N/A

Microwave ablation with margin confirmation
Device
Experimental Group · 1 Intervention: Microwave ablation · Intervention Types: Device
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Microwave ablation
2011
N/A
~500

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 24 months

Who is running the clinical trial?

Society of Interventional OncologyLead Sponsor
1 Previous Clinical Trials
9,585 Total Patients Enrolled
Constantinos Sofocleous, MD, PhD, FSIR, FCIRSEPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

Eligibility Criteria

Age 18+ · All Participants · 9 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
References

Frequently Asked Questions

How many individuals are eligible to participate in this clinical research?

"Affirmative. According to the clinicaltrial.gov website, this research project is currently accepting applicants; it was initially posted on January 13th 2023 and updated most recently on February 8th 2023. In total, 275 participants will be recruited from two distinct medical sites." - Anonymous Online Contributor

Unverified Answer

Is there an opportunity to join this medical experiment at the moment?

"Currently, the study is actively recruiting participants. This trial was initially advertised on January 13th of 2023 and has had its most recent update as recently as February 8th of this year." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top