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Vasopressor

Midodrine for Critical Illness (LIBERATE Trial)

Phase 4
Waitlist Available
Led By Oleksa G Rewa, MD MSc
Research Sponsored by University of Alberta
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

LIBERATE Trial Summary

This trial is testing whether midodrine, an oral vasopressor, can help reduce the need for IV vasopressors to treat low blood pressure in ICU patients.

Eligible Conditions
  • Critical Illness
  • Shock

LIBERATE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Duration of vasopressor support
Recruitment Rates
Secondary outcome measures
Adverse events
ICU length of stay
ICU re-admissions
+2 more

Side effects data

From 2012 Phase 4 trial • 29 Patients • NCT00108355
8%
GI Bleeding
8%
Hepatic encephalopathy
8%
Scrotal edema
100%
80%
60%
40%
20%
0%
Study treatment Arm
Albumin (Control Group)
Vasoconstrictor (Treatment Group)

LIBERATE Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: MidodrineExperimental Treatment1 Intervention
Midodrine 10mg PO/NG q8h
Group II: PlaceboPlacebo Group1 Intervention
Microcrystalline cellulose PO/NG q8h
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Midodrine
FDA approved

Find a Location

Who is running the clinical trial?

University of AlbertaLead Sponsor
888 Previous Clinical Trials
384,938 Total Patients Enrolled
4 Trials studying Critical Illness
1,780 Patients Enrolled for Critical Illness
Alberta Health servicesOTHER
158 Previous Clinical Trials
649,646 Total Patients Enrolled
3 Trials studying Critical Illness
51,771 Patients Enrolled for Critical Illness
Institute of Health Economics, CanadaOTHER
8 Previous Clinical Trials
3,283 Total Patients Enrolled
1 Trials studying Critical Illness
1,500 Patients Enrolled for Critical Illness

Media Library

Midodrine (Vasopressor) Clinical Trial Eligibility Overview. Trial Name: NCT04489589 — Phase 4
Critical Illness Research Study Groups: Placebo, Midodrine
Critical Illness Clinical Trial 2023: Midodrine Highlights & Side Effects. Trial Name: NCT04489589 — Phase 4
Midodrine (Vasopressor) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04489589 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research presently recruiting participants?

"The specified clinical trial is no longer admitting participants. This research project, initially posted on March 22nd 2021, was last updated on September 23rd 2022. For those searching for other studies related to shock and Midodrine there are 298 and 21 trials recruiting respectively."

Answered by AI

To what extent is the recruitment of participants for this trial limited?

"Unfortunately, this clinical trial has ceased recruiting patients. Initially posted on March 22nd 2021 and last updated September 23rd 2022, it is no longer open for enrolment. If you are searching for other studies related to shock, there are currently 298 trials with openings; alternatively, 21 medical studies involving Midodrine have room for more participants."

Answered by AI

What aims have researchers outlined for this research endeavor?

"This research study, with a projected timeline of one year, aims to identify the efficacy of vasopressor support. Secondary objectives include gauging all-cause patient mortality within 90 days of recruitment, calculating intensive care unit (ICU) length of stay and establishing the rate at which intravenous vasopressors need to be re-initiated during ICU admission."

Answered by AI

Is there a risk of adverse outcomes when using Midodrine?

"Data from Phase 4 trials have been analyzed and Midodrine's safety has earned a score of 3."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Midodrine for the Early Liberation of Vasopressor Support in the ICU
2021. "Midodrine for the Early Liberation of Vasopressor Support in the ICU". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04489589.
~5 spots leftby Apr 2025
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