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Midodrine for Orthostatic Intolerance in Parkinson's Disease
Study Summary
This trial will test whether the drug midodrine can reduce feelings of lightheadedness in patients with or without orthostatic hypotension (low blood pressure when standing up). It will also look at the drug's effect on blood pressure and heart rate during a physical test, and how this relates to symptom improvement.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- I am currently taking medications like phenylephrine or ephedrine.Your blood pressure when lying down is higher than 139/90 and your heart rate is lower than 60.My condition is a parkinsonian syndrome that is not Parkinson's Disease.I have difficulty understanding or making decisions due to cognitive issues.I am not pregnant, will use effective birth control, and agree to regular pregnancy tests.My kidney function is impaired (GFR <60).I have been diagnosed with Parkinson's Disease.I have been diagnosed with a drop in blood pressure when standing.I cannot stand by myself or stay standing for 5 minutes.I am currently taking medication for low blood pressure when standing.My blood pressure is over 139/90 and my heart rate is below 60.I have a history of severe heart issues, diabetes, glaucoma, arrhythmias, or difficulty urinating.You have a pacemaker.You are allergic to or have a strong sensitivity to midodrine.I feel lightheaded when I stand up but don't have low blood pressure.
- Group 1: Placebo
- Group 2: Midodrine
- Approved for 5 Other Conditions - This treatment demonstrated efficacy for 5 other conditions.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Do patients over the age of 75 years old meet the eligibility criteria for this research project?
"In order to participate in this trial, patients must be between 22 and 89 years of age. For perspective, there are 33 clinical trials for patients under 18 and 521 for patients over 65."
Who would be a qualified candidate for this research?
"This study is only looking for 50 patients that have orthostatic intolerance and are between the ages of 22 and 89."
How many people are receiving the experimental treatment?
"Unfortunately, this study is no longer looking for participants. It was initially posted on April 1st, 2014 but hasn't been updated in over 5 years. However, there are 519 other trials concerning orthostatic intolerance and 13 studies regarding Midodrine that are still taking patients."
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