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Phenylephrine for Low Blood Pressure

Phase < 1
Recruiting
Led By Noah Jouett, DO/PhD
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18 to 45 years of age
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up thirty minutes following phenylephrine infusion
Awards & highlights

Study Summary

This trial will help determine how well vasopressors work in people with low blood pressure by measuring how they affect Pulse Pressure Variability.

Who is the study for?
This trial is for adults aged 18-45 with low blood pressure who are not obese, do not smoke, and have no serious mental illnesses or history of heart, vascular, respiratory, neurological/metabolic diseases. Pregnant or breastfeeding individuals and those with renal/hepatic issues or sulfite allergies cannot participate.Check my eligibility
What is being tested?
The study tests the effects of Phenylephrine (a vasopressor) versus a saline placebo on Pulse Pressure Variability in simulated hypovolemia during surgery. It aims to inform anesthesiologists on using PPV when patients need drugs to raise blood pressure.See study design
What are the potential side effects?
Phenylephrine may cause side effects like headache, increased heart rate, irregular heartbeat, high blood pressure spikes and possibly anxiety. Reactions can vary from person to person.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 45 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~thirty minutes following phenylephrine infusion
This trial's timeline: 3 weeks for screening, Varies for treatment, and thirty minutes following phenylephrine infusion for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pulse Pressure Variability

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: PhenylephrineExperimental Treatment1 Intervention
Phenylephrine infusion (0.3 mcg/kg/hr)
Group II: ControlPlacebo Group1 Intervention
Saline infusion
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Phenylephrine
2014
Completed Phase 4
~2050

Find a Location

Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor
1,048 Previous Clinical Trials
1,053,769 Total Patients Enrolled
Texas Health ResourcesOTHER
14 Previous Clinical Trials
20,134 Total Patients Enrolled
Noah Jouett, DO/PhDPrincipal InvestigatorUniversity of Texas Southwestern Medical Center

Media Library

Phenylephrine Clinical Trial Eligibility Overview. Trial Name: NCT05011357 — Phase < 1
Intraoperative Hypotension Research Study Groups: Phenylephrine, Control
Intraoperative Hypotension Clinical Trial 2023: Phenylephrine Highlights & Side Effects. Trial Name: NCT05011357 — Phase < 1
Phenylephrine 2023 Treatment Timeline for Medical Study. Trial Name: NCT05011357 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What precedent exists in terms of trials involving Phenylephrine?

"Presently, 26 clinical trials are exploring Phenylephrine with 5 of them currently in Phase 3. While most studies for this medication are conducted in New Haven, Connecticut, it is being trialed across 37 different locations."

Answered by AI

Is it possible for me to volunteer in this clinical experiment?

"The eligibility requirements of the trial necessitate that potential participants have hypotension and fall within the ages of 18 and 45. This medical study is accepting 6 patients."

Answered by AI

In what medical settings is Phenylephrine typically utilized?

"Phenylephrine is regularly administered to alleviate bronchial congestion, but can also be utilized to treat sinus blockage, allergic rhinitis, and inflammation in the eyes."

Answered by AI

Does this clinical trial maintain an age limit, and if so, who is eligible to participate?

"This experiment is enrolment people of legal age and younger than 45 years old."

Answered by AI

What is the aggregate of individuals participating in this experiment?

"That is accurate. According to the details posted on clinicaltrials.gov, this medical research study initially went live on September 10th 2021 and its information was recently updated at the end of January 2022. The trial seeks 6 individuals across 2 sites for enrollment."

Answered by AI

Are there any slots still available for participation in this experiment?

"The details presented on clinicaltrials.gov illustrate that recruitment for this medical trial is currently ongoing; the first posting was made on September 10th 2021 and the most recent edit occurred January 31st 2022."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Phenylephrine and Pulse Pressure Variability
Noah Jouett 2021. "Phenylephrine and Pulse Pressure Variability". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05011357.
~0 spots leftby Jun 2024
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