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Corticosteroid

YUTIQ Injections for Uveitis (TYNI Trial)

Phase 3
Recruiting
Research Sponsored by Texas Retina Associates
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Not planning to undergo elective ocular surgery during the study
Presence of active posterior segment inflammation as determined by the Investigator
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

TYNI Trial Summary

This trial found that using two YUTIQ injections was more effective than a sham injection for treating chronic non-infectious intraocular inflammation.

Who is the study for?
Adults in good health with chronic noninfectious inflammation in the back part of the eye, who've responded to steroids before, can join. They must understand and sign consent forms, follow study rules, and not be planning eye surgery during the trial. Pregnant women or those with certain other eye conditions or high eye pressure are excluded.Check my eligibility
What is being tested?
The TYNI Trial is testing if two implants of a drug called YUTIQ are better than a fake treatment (sham) for long-term inflammation inside the eye that doesn't come from an infection. Participants will either get YUTIQ implants or sham injections to compare effectiveness.See study design
What are the potential side effects?
YUTIQ may cause increased pressure inside the eye, cataracts, temporary visual blurring after implantation, and possibly some discomfort at the injection site. The exact side effects experienced can vary between individuals.

TYNI Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am not planning any eye surgery during the study.
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I have active inflammation in the back part of my eye.
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My eye inflammation is moderate to severe.
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I have long-term eye inflammation that improved with steroids but came back.

TYNI Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Recurrence rate of uveitis will be assessed at the 6-month visit
Secondary outcome measures
Uveitis

TYNI Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Treatment ArmExperimental Treatment1 Intervention
This group will receive two YUTIQ implants at day 1.
Group II: Control ArmPlacebo Group1 Intervention
This group will receive two sham injections at day 1.

Find a Location

Who is running the clinical trial?

Texas Retina AssociatesLead Sponsor
5 Previous Clinical Trials
250 Total Patients Enrolled
1 Trials studying Uveitis
12 Patients Enrolled for Uveitis
Eye Point PharmaceuticalsUNKNOWN

Media Library

Yutiq 0.18 MG Drug Implant (Corticosteroid) Clinical Trial Eligibility Overview. Trial Name: NCT05486468 — Phase 3
Uveitis Research Study Groups: Treatment Arm, Control Arm
Uveitis Clinical Trial 2023: Yutiq 0.18 MG Drug Implant Highlights & Side Effects. Trial Name: NCT05486468 — Phase 3
Yutiq 0.18 MG Drug Implant (Corticosteroid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05486468 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are possible adverse effects of the Yutiq 0.18 MG Drug Implant?

"Yutiq 0.18 MG Drug Implant is classified as a phase 3 medication, which means that while there is some evidence of its efficacy, multiple rounds of testing have confirmed its safety."

Answered by AI

Are people currently being recruited for this research project?

"Yes, the information on clinicaltrials.gov points out that this study is presently recruiting patients. The clinical trial was first posted on 10/5/2022 and was most recently edited on 10/27/2022. The clinical trial is enrolling 30 participants between 1 sites"

Answered by AI

What is the total sample size for this research project?

"That is correct. The clinicaltrials.gov website indicates that this research is actively recruiting patients. This trial was originally posted on October 5th, 2020 and edited most recently on October 27th, 2020. They are looking for a total of 30 people to participate at 1 location."

Answered by AI
~12 spots leftby Apr 2025