MOx Diet for Enteric Hyperoxaluria
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial involves participants eating high oxalate foods and taking a specific substance to study how their bodies handle oxalate. It targets patients with IBD, post-RYGB patients with kidney stones, and healthy individuals. Researchers will collect various samples to understand oxalate processing.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, healthy controls must not be on any chronic medications to participate.
Is the MOx Diet safe for humans?
How does the MOx Diet treatment for enteric hyperoxaluria differ from other treatments?
What data supports the effectiveness of the MOx Diet treatment for enteric hyperoxaluria?
Research shows that a low-oxalate diet can significantly reduce urinary oxalate levels, which is beneficial for people with hyperoxaluria. In one study, patients on a low-oxalate diet saw a decrease in urinary oxalate excretion, suggesting that dietary modifications can help manage this condition.12368
Who Is on the Research Team?
Lama Nazzal, MD
Principal Investigator
NYU Langone Health
David Goldfarb, MD
Principal Investigator
NYU Langone Health
Are You a Good Fit for This Trial?
Adults aged 18-80 with IBD or post-RYGB surgery, who've had a kidney stone or related event in the last three years can join. It's open to all races and genders but not for pregnant/nursing women, those with recent antibiotics use, colectomy patients, active IBD flare-ups, or significantly impaired kidney function.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Dietary Intervention
Participants are administered a high oxalate diet on Days 0-3 and Days 21-24, with a washout period on Days 4-7, and 250mg sodium oxalate on Days 8-20
Sample Collection
Participants partake in four stool collections, four 24-h urine collections, two blood collections, and four sets of colonic permeability testing
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Moderately High Oxalate (MOx) Diet
Find a Clinic Near You
Who Is Running the Clinical Trial?
NYU Langone Health
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator