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LSD1 Inhibitor

Bomedemstat for Essential Thrombocythemia

Phase 2
Waitlist Available
Research Sponsored by Imago BioSciences,Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to approximately 30 months
Awards & highlights

Study Summary

This trial will enroll approximately 100 participants.

Eligible Conditions
  • Essential Thrombocythemia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to approximately 30 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to approximately 30 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants Who Discontinued Study Treatment Due to an AE
Number of Participants Who Experienced an Adverse Event (AE)
Percentage of Participants With Platelet Count ≤400 k/μL at Day 169

Side effects data

From 2022 Phase 1 & 2 trial • 90 Patients • NCT03136185
88%
Thrombocytopenia
63%
Nausea
50%
Oedema peripheral
38%
Pneumonia
38%
Diarrhoea
38%
Dysgeusia
25%
Pyrexia
25%
Pollakiuria
25%
Hot flush
25%
Fatigue
25%
Anaemia
25%
Constipation
25%
COVID-19
25%
Vomiting
25%
Hypoalbuminaemia
25%
Decreased appetite
25%
Muscular weakness
25%
Pain in extremity
25%
Myalgia
25%
Chronic obstructive pulmonary disease
25%
Epistaxis
25%
Hypotension
25%
Tachycardia
13%
Dry mouth
13%
Conjunctivitis
13%
Contusion
13%
Upper respiratory tract infection
13%
Cardiac murmur
13%
Hyperuricaemia
13%
Nephrolithiasis
13%
Pruritus
13%
Rash
13%
Small intestinal haemorrhage
13%
Rectal haemorrhage
13%
Influenza
13%
Neutropenia
13%
Septic shock
13%
Headache
13%
Dyspnoea
13%
Respiratory failure
13%
Ocular hyperaemia
13%
Bradycardia
13%
Lymphopenia
13%
Abdominal distension
13%
Abdominal pain
13%
Oral pain
13%
Erysipelas
13%
Fall
13%
Skin infection
13%
Blood alkaline phosphatase increased
13%
Activated partial thromboplastin time prolonged
13%
Parkinson's disease
13%
Blood lactate dehydrogenase increased
13%
Blood uric acid increased
13%
Blood sodium decreased
13%
Blood calcium decreased
13%
Blood potassium decreased
13%
Increased appetite
13%
Blood glucose increased
13%
Hypokalaemia
13%
Prothrombin time prolonged
13%
Hypophosphataemia
13%
Blood phosphorus decreased
13%
Weight decreased
13%
Paraesthesia
13%
Genital rash
13%
Muscle spasms
13%
Musculoskeletal pain
13%
Hypoxia
13%
Cough
13%
Rhinorrhoea
13%
Rash maculo-papular
13%
Decubitus ulcer
13%
Nail dystrophy
13%
Hypertension
100%
80%
60%
40%
20%
0%
Study treatment Arm
Ph 2b PMF: Bomedemstat 0.5 mg/kg/d
Ph 1/2a PMF: Bomedemstat 0.25 mg/kg/d
Ph 2b PET-MF: Bomedemstat 0.6 mg/kg/d
Ph 1/2a PPV-MF: Bomedemstat 0.25 mg/kg/d
Ph 1/2a PET-MF: Bomedemstat 0.25 mg/kg/d
Ph 2b PET-MF: Bomedemstat 0.5 mg/kg/d
Ph 2b PPV-MF: Bomedemstat 0.5 mg/kg/d
Ph 2b PMF: Bomedemstat 0.6 mg/kg/d
Ph 2b PPV-MF: Bomedemstat 0.6 mg/kg/d

Trial Design

1Treatment groups
Experimental Treatment
Group I: BomedemstatExperimental Treatment1 Intervention
Bomedemstat administered daily for 169 consecutive days
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bomedemstat
2017
Completed Phase 2
~170

Find a Location

Who is running the clinical trial?

Imago BioSciences,Inc.Lead Sponsor
9 Previous Clinical Trials
371 Total Patients Enrolled
Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., (Rahway, New Jersey USA)Lead Sponsor
9 Previous Clinical Trials
371 Total Patients Enrolled
Hugh Rienhoff, MDStudy DirectorImago BioSciences
2 Previous Clinical Trials
100 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many healthcare establishments are currently conducting this research?

"The ongoing trial is being conducted in 7 different medical centres, including Ann Arbor, Durham and Jacksonville. To reduce travel time and costs, it is best to pick the most convenient clinic for you if you plan on enrolling."

Answered by AI

Is this a pioneering exploration of its kind?

"IMG-7289 has been investigated since 2020, when the original study sponsored by Imago BioSciences Inc. was launched with an enrollment of 20 participants. After receiving Phase 2 drug approval following its initial exploration in 2020, there are now 4 current experiments for IMG-7289 taking place across 7 different countries and 15 cities globally."

Answered by AI

Are there any precedents of research into IMG-7289's efficacy?

"Currently, four active clinical trials are evaluating the effects of IMG-7289 with none in Phase 3. A multitude of medical centres located in Jena and Victoria are running these studies while 28 other sites worldwide have launched investigations into the efficacy of this drug."

Answered by AI

Is there still availability for those interested in participating in this experiment?

"At this moment, recruitment for the trial has paused. This medical study was first added to clinicaltrials.gov on September 20th 2020, and subsequently updated on April 15th 2022; however, if you are searching for alternatives there are 51 trials involving thrombocythemia essential, as well as 4 studies focusing on IMG-7289 that have begun admitting patients."

Answered by AI

Has the FDA granted authorization to IMG-7289?

"IMG-7289 has been evaluated as a level 2 on our safety scale; this Phase 2 trial provides evidence of its security, but there are no published studies validating its efficacy."

Answered by AI

What is the current size of this clinical trial's cohort?

"At this moment, patient recruitment has been paused for this clinical trial. The study was initially made available to the public on September 20th 2020 and its details were last edited April 15th 2022. Individuals looking for additional studies may find 51 trials actively enrolling patients with thrombocythemia or essential IMG-7289 is being studied in four separate medical investigations which are currently open to enrollment."

Answered by AI
~16 spots leftby Apr 2025