← Back to Search

CBD for Persistent Post-Surgical Pain After Knee Replacement

Q: Is there precedent for CBD as a medication?

<p>As of now, 83 clinical trials for Cannabidiol (<a href="https://www.withpower.com/clinical-trials/cbd">CBD</a>) are ongoing. Of these, 18 are in Phase 3. The numerous studies for Cannabidiol (CBD) have their origins in Ribeirao Preto, Sao Paulo, but expanded to 311 locations.</p>

Phase 3

Recruiting

Led By Vahid Ashoorion, MD, PhD

Research Sponsored by McMaster University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24-48 hours, 2-weeks, 6-weeks, 3-months and 6-months

Awards & highlights

Study Summary

This trial will assess whether adding CBD to usual care before and after surgery can reduce the rate of persistent post-surgical pain after total knee replacement.

Who is the study for?

This trial is for adults over 18 who are having knee replacement surgery and can understand English. They must be able to follow the study's steps and not have other chronic pain conditions, severe heart/lung disease, substance use disorders, or allergies to cannabis. Pregnant or breastfeeding individuals cannot participate.Check my eligibility

What is being tested?

The study tests if a CBD dominant oil (MPL-001) reduces long-term pain after knee surgery compared to a placebo oil. Participants will be randomly assigned to one of these two options and monitored for six months to see how well they do with their usual care plus the test product.See study design

What are the potential side effects?

While specific side effects aren't listed here, CBD products may cause tiredness, changes in appetite or weight, diarrhea, and sometimes mood changes. THC can lead to feeling 'high', but since it's much less than CBD in this mix, that effect might be minimal.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24-48 hours, 2-weeks, 6-weeks, 3-months and 6-months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24-48 hours, 2-weeks, 6-weeks, 3-months and 6-months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24-48 hours, 2-weeks, 6-weeks, 3-months and 6-months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Persistent post-surgical pain (PPSP)

Secondary outcome measures

Anxiety and depression

Insomnia

Mental function

+6 more

Other outcome measures

Feasibility - compliance

Feasibility - recruitment

Feasibility - retention

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: MPL-001 (CBD: THC 25:1)Experimental Treatment1 Intervention

125mg CBD/5 mg THC oil for oral use

Group II: PlaceboPlacebo Group1 Intervention

Visually identical placebo (medium chain triglyceride oil)

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Hamilton Health Sciences CorporationOTHER

368 Previous Clinical Trials

300,961 Total Patients Enrolled

2 Trials studying Osteoarthritis

233 Patients Enrolled for Osteoarthritis

McMaster UniversityLead Sponsor

884 Previous Clinical Trials

2,598,276 Total Patients Enrolled

20 Trials studying Osteoarthritis

901,130 Patients Enrolled for Osteoarthritis

St. Joseph's Healthcare HamiltonOTHER

196 Previous Clinical Trials

25,504 Total Patients Enrolled

1 Trials studying Osteoarthritis

64 Patients Enrolled for Osteoarthritis

Media Library

MPL-001 (CBD: THC 25:1) Clinical Trial Eligibility Overview. Trial Name: NCT03825965 — Phase 3

Osteoarthritis Research Study Groups: MPL-001 (CBD: THC 25:1), Placebo

Osteoarthritis Clinical Trial 2023: MPL-001 (CBD: THC 25:1) Highlights & Side Effects. Trial Name: NCT03825965 — Phase 3

MPL-001 (CBD: THC 25:1) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03825965 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has the FDA released any guidance on CBD usage?

"There is some evidence that CBD is effective, and it has been studied multiple times, so it received a score of 3."

Answered by AI

Is there precedent for CBD as a medication?

"As of now, 83 clinical trials for Cannabidiol (CBD) are ongoing. Of these, 18 are in Phase 3. The numerous studies for Cannabidiol (CBD) have their origins in Ribeirao Preto, Sao Paulo, but expanded to 311 locations."

Answered by AI