Cannabidiol (CBD) for Pain, Postoperative

Phase-Based Estimates
2
Effectiveness
3
Safety
Hamilton Health Sciences - Juravinski Hospital, Hamilton, Canada
Pain, Postoperative+2 More
Cannabidiol (CBD) - Drug
Eligibility
18+
All Sexes
Eligible conditions
Pain, Postoperative

Study Summary

This study is evaluating whether a drug called CBD can reduce pain after knee replacement surgery.

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Eligible Conditions

  • Pain, Postoperative
  • Osteoarthritis, Knee
  • Osteoarthritis of the Knee

Treatment Effectiveness

Effectiveness Estimate

2 of 3
This is better than 85% of similar trials

Study Objectives

This trial is evaluating whether Cannabidiol (CBD) will improve 1 primary outcome, 9 secondary outcomes, and 3 other outcomes in patients with Pain, Postoperative. Measurement will happen over the course of 6 months.

Hour 48
Pain interference
Peri-operative pain intensity
6 months
Anxiety and depression
Feasibility - compliance
Feasibility - recruitment
Feasibility - retention
Insomnia
Mental function
Opioid use
Persistent post-surgical pain (PPSP)
Physical function
Return to function
Safety - Adverse events

Trial Safety

Safety Estimate

3 of 3
This is better than 85% of similar trials

Trial Design

2 Treatment Groups

Placebo
Cannabidiol (CBD)
Placebo group

This trial requires 40 total participants across 2 different treatment groups

This trial involves 2 different treatments. Cannabidiol (CBD) is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 3 and have had some early promising results.

Cannabidiol (CBD)
Drug
Oral medicinal cannabis (125 mg cannabidiol daily suspended in oil)
Placebo
Drug
Visually identical placebo (medium chain triglyceride oil)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cannabidiol
FDA approved

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 24-48 hours, 2-weeks, 6-weeks, 3-months and 6-months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 24-48 hours, 2-weeks, 6-weeks, 3-months and 6-months for reporting.

Closest Location

Hamilton Health Sciences - Juravinski Hospital - Hamilton, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Patients undergoing TKA aged 18 or older
The cognitive ability and English-language skills necessary to complete the outcome measures are required. show original
Provision of informed consent
is a key determinant of the long-term success of a project show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of pain, postoperative?

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Pain severity in the postoperative period is a major problem and a patient's general state and condition are also a major determinant of their postoperative pain. The more the patient has undergone a previous operation, is younger and has some other health problems, the more likely they will suffer pain postoperatively. In addition, older patients suffer pain during operations involving major trauma (e.g., brain, spinal, cardiovascular, etc.) and they are more likely to experience more severe postoperative pain. Moreover, in general anesthesia patients, the extent of postoperative pain can be minimized by preventing and then treating the condition triggering the pain in order to reduce the number and severity of postoperative pains.

Unverified Answer

What are common treatments for pain, postoperative?

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Common treatments for pain include analgesics, NSAIDs, opioids, and antipyretics. Other important issues involved in the care of the postoperative patient are addressing nutritional deficiencies (including calcium, magnesium, and vitamin D), monitoring physiologic parameters, and providing emotional support during the postoperative period.

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What is pain, postoperative?

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Results from a recent clinical trial demonstrates pain to be a significant problem in both the ICU and in the acute general ward. It also demonstrates that pain management is an ongoing challenge; however patients receive analgesia they will continue to experience pain despite receiving the analgesia and suffer from further distress. Effective communication is also necessary and essential to ensure patient satisfaction but also efficient use of resources and staff and patients overall well-being.

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Can pain, postoperative be cured?

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Many patients are not benefiting from postoperative pain as intended. Thus, pain management is a missed opportunity in some surgical clinics. We identified several possible solutions that could help us improve our postoperative pain management: more patient education before surgery and clearer explanations after surgery.

Unverified Answer

What causes pain, postoperative?

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Pain is prevalent in postoperative settings, and there is growing knowledge that pain is associated with other patient centered outcomes, such as length of stay or readmission. This information can be used to reduce pain, which in turn can have significant economic and human value. Further research is needed to understand whether the prevalence of postoperative pain and how pain is managed, and to develop strategies to identify patients needing more comprehensive pain management.

Unverified Answer

How many people get pain, postoperative a year in the United States?

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Half of the US population has major surgical, hospital, and procedural pain annually. While the reasons for pain are a wide variety of considerations, patients have an urgent need to be well prepared for future pain after surgery or hospital care. Hospitals and health plans are not protecting themselves, and the public, from excessive postoperative pain.

Unverified Answer

What does cannabidiol (cbd) usually treat?

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CBD's are not a specific therapy, there is a lot of evidence to support that CBD's can be used as a therapeutic tool to combat anxiety symptom severity. CBD can be administered intravenously or via oral ingestion and there is very limited evidence to support the use of CBD in managing PONV. In general, there is insufficient data to support CBD as a single therapeutic choice for managing PONV. The role that CBD can potentially play in other GI conditions is unclear, and thus further research is required.

Unverified Answer

What is the primary cause of pain, postoperative?

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The primary cause of pain in our patient population was mostly benign conditions. However, given its frequency and severity, postoperative pain should be systematically and carefully investigated. In fact, when pain persists or when patients are not satisfied with the care, an evaluation in a specialty center may be helpful.

Unverified Answer

How serious can pain, postoperative be?

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Serious postoperative pain can be both under-reported and overlooked. Patients may have pain if they have not been offered pain management and patients may not have been given proper instructions or adequate pain relief upon discharge, which can result in under-treating.

Unverified Answer

What is the average age someone gets pain, postoperative?

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On average, people with pain due to elective surgery feel their pain 1 month after surgery. The percentage of people who feel pain more than 3 months after surgery is higher than the percentage of people with pain less than 3 months after surgery. Pain after surgery is a substantial issue for people and many do not feel like they get the treatment they need. Because of this, it is important that the average age a person feels postoperative pain is understood and understood correctly by healthcare providers.

Unverified Answer

Who should consider clinical trials for pain, postoperative?

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The potential positive effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on postoperative pain are well documented. However, it is difficult to determine the correct dosage of NSAIDs for pain control after surgery. In our experience, intravenous (IV) opiates are equally effective and safer than oral (PO) oral analgesics with minimal or no adverse effects. We would recommend clinical trials of NSAIDs in pain following surgery.

Unverified Answer

Does cannabidiol (cbd) improve quality of life for those with pain, postoperative?

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The CBD+TMPS regimen significantly improves HRQOL for patients with a common chronic condition of moderate to high severity. The positive effects on pain and general wellbeing are significant when these measures are employed together as outcome measures. Clinically significant and durable improvements in quality of life for the majority of patients receiving CBD+TMPS (n=27) compared to traditional medical care suggests a therapeutic benefit.

Unverified Answer
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