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Bupivacaine for Cervical Cancer

Phase 3
Waitlist Available
Led By Clare Reade, MD
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients aged 18 and above undergoing elective gynecologic oncology surgery for a suspected malignancy using a midline laparotomy incision.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 4, 8, 12, 16, 20, 24, 30, 36, 42 and 48 hours after surgery
Awards & highlights

Study Summary

This trial is studying whether giving a local anesthetic in the abdominal wall after surgery can reduce the amount of opioids needed for pain relief and improve recovery for women undergoing surgery for a suspected gynecologic malignancy.

Eligible Conditions
  • Cervical Cancer
  • Surgical Procedure

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 hours after surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours after surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Total dose of opioid (in morphine equivalents) received in the postoperative period
Secondary outcome measures
Incidence of clinical ileus
Postoperative nausea and vomiting rates
Postoperative pain scores
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: BupivacaineExperimental Treatment1 Intervention
Administration of 20ml of bupivacaine 0.25% on each side, for a total of 40ml.
Group II: SalinePlacebo Group1 Intervention
Administration on 20ml of normal saline on each side, for a total of 40ml.

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
884 Previous Clinical Trials
2,598,236 Total Patients Enrolled
Clare Reade, MDPrincipal InvestigatorMcMaster University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Trial Comparing Surgeon-administered TAP Block With Placebo After Midline Laparotomy in Gynecologic Oncology
Laurence Bernard 2020. "A Trial Comparing Surgeon-administered TAP Block With Placebo After Midline Laparotomy in Gynecologic Oncology". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04202874.
~18 spots leftby Apr 2025
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