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Checkpoint Inhibitor

Rucaparib for Endometrial Cancer (EndoBARR Trial)

Phase 2
Waitlist Available
Led By William Bradley, MD
Research Sponsored by Medical College of Wisconsin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 48-60 months
Awards & highlights

EndoBARR Trial Summary

This trial is testing a combination of drugs to treat endometrial cancer that has come back or is getting worse.

Eligible Conditions
  • Endometrial Cancer
  • Uterine Carcinosarcoma

EndoBARR Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~48-60 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 48-60 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Overall Response Rate
Secondary outcome measures
Number of participants with treatment-related adverse events as assessed by CTCAE V5.0
Overall Survival
Progression Free Survival
Other outcome measures
Cardiac toxicity
Circulating tumor DNA
Homologus recombination deficiency gene alterations
+5 more

EndoBARR Trial Design

1Treatment groups
Experimental Treatment
Group I: TreatmentExperimental Treatment3 Interventions
Cycle length = 21 days Atezolizumab 1,200mg IV on day 1 Bevacizumab 15mg/kg IV on day 1 Rucaparib 600mg orally twice daily by continuous dosing
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Rucaparib
2016
Completed Phase 3
~1990
Bevacizumab
2013
Completed Phase 4
~5280
Atezolizumab
2017
Completed Phase 3
~5860

Find a Location

Who is running the clinical trial?

Clovis Oncology, Inc.Industry Sponsor
64 Previous Clinical Trials
11,641 Total Patients Enrolled
2 Trials studying Endometrial Cancer
61 Patients Enrolled for Endometrial Cancer
Medical College of WisconsinLead Sponsor
609 Previous Clinical Trials
1,162,553 Total Patients Enrolled
Genentech, Inc.Industry Sponsor
1,540 Previous Clinical Trials
567,869 Total Patients Enrolled
6 Trials studying Endometrial Cancer
436 Patients Enrolled for Endometrial Cancer

Media Library

Atezolizumab (Checkpoint Inhibitor) Clinical Trial Eligibility Overview. Trial Name: NCT03694262 — Phase 2
Endometrial Cancer Research Study Groups: Treatment
Endometrial Cancer Clinical Trial 2023: Atezolizumab Highlights & Side Effects. Trial Name: NCT03694262 — Phase 2
Atezolizumab (Checkpoint Inhibitor) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03694262 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people have signed up to participate in this medical research?

"As of 4/4/2022, this clinical trial is not currently seeking more candidates. This study was first posted on 7/19/2019 and has had no recent updates. However, there are 317 other trials for mixed tumor, mullerian patients and 674 studies involving Atezolizumab that are still looking for participants."

Answered by AI

For what purpose is Atezolizumab most frequently prescribed?

"Atezolizumab can be used to fight ovarian cancer that has returned despite platinum-based treatment, as well as other malignant neoplasms and peritoneal cancers."

Answered by AI

What are some other experiments that have been done using Atezolizumab?

"Atezolizumab was first studied in 2004 at Memoral Sloan Kettering Basking Ridge. So far, 1091 trials have been completed with 674 currently active. New york City has a high density of these ongoing studies."

Answered by AI

Has Atezolizumab received government backing for public use?

"Atezolizumab's efficacy is unproven, but it has received a score of 2 due to prior clinical data suggesting that it is safe."

Answered by AI

Is patient enrollment still open for this clinical trial?

"This trial, as indicated on clinicaltrials.gov, is not currently looking for patients but was most recently updated on 4/4/2022. There are 991 other trials that are currently recruiting patients."

Answered by AI
Recent research and studies
~5 spots leftby Apr 2025