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Combination Drug Therapy for Glioblastoma
Study Summary
This trial is testing a new combination drug therapy for people with brain cancer that has come back or gotten worse after other treatments.
- Glioblastoma
Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- You have experienced dangerous episodes of high blood pressure in the past.You had a heart attack or unstable chest pain in the last 6 months.You have received chemotherapy treatment within the past 4 weeks.You have taken procarbazine within the past 3 weeks.You have had a hole or tear in your stomach or intestines within the past 6 months.You have allergies to the substances used in this study.You are currently taking herbal medications.You have a severe wound, ulcer, or broken bone that is not healing or being treated.You had a stroke or mini-stroke (TIA) within the past 6 months.Your disease has gotten worse after receiving radiation therapy and TMZ treatment. You can have multiple relapses, as long as you still meet the other requirements for joining the study.You have taken nitrosoureas within the past 6 weeks.You have a medical condition that could make it difficult to determine if the treatment is working or if it could affect how your body processes the drug in a dangerous way.You have moderate to severe heart failure according to the New York Heart Association classification.You have had a significant amount of bright red blood when coughing within the past month.You have recently had a major blood vessel problem, like an aneurysm or a blockage in your arms or legs.This assessment will be done when the tumor comes back and after you finish your previous treatment.
- Group 1: Treatment Arm
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Does this research have any vacancies for participants?
"According to clinicaltrials.gov, enrolment for this medical research project is ongoing. The experiment was first published on November 1st 2015 and last modified on September 13th 2022."
How many participants are accepted for this clinical experiment?
"Affirmative. Clinicaltrials.gov records demonstrate that this medical research initiative, which was initially posted on November 1st of 2015, is presently recruiting patients. 10 human subjects are being sought from a single location for the trial's duration."
Has the FDA sanctioned Combination Drug Therapy?
"Our team at Power assessed the safety of Combination Drug Therapy to be a 1, as this is an initial phase trial with minimal evidence validating its efficacy and security."
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