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Flavonoid

Isoquercetin for Sickle Cell Disease

Phase 2
Waitlist Available
Led By Arun S Shet, M.D.
Research Sponsored by National Heart, Lung, and Blood Institute (NHLBI)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to day 56
Awards & highlights

Study Summary

This trial is testing whether a dietary supplement called Isoquercetin can decrease levels of inflammation and blood clotting in people with Sickle Cell Disease.

Eligible Conditions
  • Sickle Cell Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to day 56
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to day 56 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean Change in the Plasma Soluble P-selectin Level
Secondary outcome measures
Mean Change in D-Dimer
Mean Change in Plasma Protein Disulfide Isomerase Activity
Mean Change in Tissue Factor Vesicle Procoagulant Activity
+6 more

Side effects data

From 2019 Phase 2 & 3 trial • 64 Patients • NCT02195232
14%
Diarrhea
7%
Nausea
4%
Constipation
4%
Epistaxis
4%
Hyponatremia
4%
Weight loss
4%
Bruising
100%
80%
60%
40%
20%
0%
Study treatment Arm
Cohort A (Isoquercetin 500 mg)
Cohort B (Isoquercetin 1000 mg)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Participants with Sickle Cell Disease Receiving IsoquercetinExperimental Treatment1 Intervention
Isoquercetin 1000 mg, once daily by mouth for 28 days in participants with Sickle Cell Disease.
Group II: Participants with Sickle Cell Disease Receiving PlaceboPlacebo Group1 Intervention
Placebo once daily, by mouth for 28 days in participants with Sickle Cell Disease.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Isoquercetin
2020
Completed Phase 3
~180

Find a Location

Who is running the clinical trial?

Quercis Pharma AGIndustry Sponsor
1 Previous Clinical Trials
150 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)Lead Sponsor
3,835 Previous Clinical Trials
47,310,596 Total Patients Enrolled
Arun S Shet, M.D.Principal InvestigatorNational Heart, Lung, and Blood Institute (NHLBI)
4 Previous Clinical Trials
2,170 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease
2020. "Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04514510.
~10 spots leftby Apr 2025
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