What side effects are associated with this type of intervention?

Common side effects of light therapy for wound healing include mild skin irritation, redness, and a sensation of warmth at the treatment site. Temporary changes in skin pigmentation, such as hyperpigmentation or hypopigmentation, can also occur. Other treatments, like photodynamic therapy, may cause photosensitivity, increasing the risk of sunburn. Severe side effects are rare but can include allergic reactions to topical agents used alongside light therapy.

What prior FDA approvals exist?

The FDA has approved several treatments for wound healing that enhance cellular activity and promote tissue regeneration. These include various forms of phototherapy and laser therapy, such as low-level laser therapy (LLLT) and light-emitting diode (LED) therapy. These treatments work by stimulating cellular processes, increasing blood flow, and promoting the production of collagen and other essential proteins for tissue repair. Additionally, other FDA-approved treatments include platelet-rich plasma (PRP) therapy, which uses concentrated platelets to accelerate healing, and certain topical agents that support cellular regeneration.

What other types of research exist?

Promising novel alternatives to light therapy for wound healing include: <ol> <li>Platelet-Rich Plasma (PRP) Therapy: Utilizes concentrated platelets from the patient's blood to accelerate healing and tissue regeneration.</li> <li></li> </ol> Stem Cell Therapy: Involves the use of stem cells to promote repair and regeneration of damaged tissues. 3. Growth Factor Therapy: Uses growth factors to stimulate cellular proliferation and tissue repair. 4. Hyperbaric Oxygen Therapy (HBOT): Enhances oxygen delivery to tissues, promoting faster healing. 5. Bioengineered Skin Substitutes: Includes products like artificial skin grafts that support tissue regeneration.

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LED Light Therapy for Wound Healing

N/A

Waitlist Available

Led By Kristen Kelly, MD

Research Sponsored by University of California, Irvine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adults aged 18 years or older with no active cutaneous disease on bilateral ventral biceps, close to the axilla.

Subjects shall have given written informed consent for both the LED therapy and for clinical photography.

Must not have

Subjects are taking any systemic drug or applying any topical drug with known photosensitizing properties.

Subjects taking any systemic drug with known immunosuppressant properties.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 56 days

Awards & highlights

Summary

This triallooks at how light therapy can help heal wounds after laser treatment. #LightTherapy #WoundHealing

Who is the study for?

This trial is for adults over 18 with no skin diseases near the underarm area who can consent to LED therapy and clinical photos. It's not for those on photosensitizing drugs, with epilepsy, cancer in the treatment area, using medications at the site, poor compliance risk, recent smokers, steroid users or those refusing consent.Check my eligibility

What is being tested?

The study tests Celluma POD light therapy's effectiveness on healing after laser treatments. Participants will receive combined red and near-infrared LED therapy to see how it helps tissue regeneration.See study design

What are the potential side effects?

Potential side effects may include skin irritation or increased sensitivity to light due to exposure from the LED device used during therapy.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am over 18 and have no skin disease near my underarms.

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I have signed consent forms for LED therapy and clinical photos.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am not using any drugs known to increase sensitivity to sunlight.

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I am not taking any drugs that weaken my immune system.

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I have epilepsy or a history of seizures.

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I am currently receiving cortisone or other steroid injections.

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My cancer has spread to other parts of my body.

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I am not applying any medications to the inner part of my upper arm.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 56 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~56 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 56 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Days to healing

Secondary outcome measures

Pain level

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: LED treatmentExperimental Treatment1 Intervention

LED treatment with Celluma POD device after laser test area

Group II: ControlActive Control1 Intervention

No treatment after laser test area

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Celluma POD

2021

N/A

~30

0 / 8Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Light therapy, including low-level laser therapy (LLLT) and photobiomodulation, enhances cellular activity and promotes tissue regeneration by stimulating mitochondrial activity, increasing ATP production, and enhancing cell proliferation and migration. It also reduces inflammation by modulating cytokine levels and promotes collagen synthesis, crucial for tissue repair. These mechanisms accelerate wound closure, improve skin repair quality, and reduce infection and scarring risks, making them highly beneficial for wound healing patients.

Mesenchymal stromal cell-secretome for therapeutic application in skin wound healing: a systematic review of preclinical studies.Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice.The use of light photobiomodulation on the treatment of second-degree burns: a histological study of a rodent model.