18F-4FN PET Imaging Agent for Inflammation Detection
LF
Overseen ByLesley Flynt, MD
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: M.D. Anderson Cancer Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Trial Summary
What is the purpose of this trial?
This trial tests a new imaging dye called 18F-4FN for special scans. It aims to help doctors see inflammation in patients, especially those with immune-related issues. The dye works by sticking to chemicals produced during inflammation, making these areas visible on scans.
Research Team
LF
Lesley Flynt, MD
Principal Investigator
M.D. Anderson Cancer Center
Eligibility Criteria
Adults diagnosed with endocrine tumors or inflammation due to immune checkpoint inhibitors can join. They must have normal kidney and liver function, not be allergic to the test substance, and weigh less than 400 pounds. Pregnant women, lactating mothers, and children under 18 are excluded.Inclusion Criteria
My kidney and liver function tests are within normal ranges.
I am 18 years old or older.
I have a tumor and have had side effects from immune therapy or suspected inflammation.
Exclusion Criteria
I am 18 years old or older.
You weigh more than 400 pounds or your body mass index (BMI) is too high for the PET/CT scanner to safely support your weight.
I am not allergic to [18F]4FN.
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Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants receive 1 injection of 18F-4FN for PET imaging
1 day
1 visit (in-person)
Follow-up
Participants are monitored for safety and biodistribution after the injection
4 weeks
Treatment Details
Interventions
- 4-[18F]Fluoro-1-Naphthol
Trial OverviewThe trial is testing a new PET imaging agent called 18F-4FN that may help visualize inflammation in patients with endocrine neoplasia by highlighting areas where certain immune cells gather.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: 4-[18F]Fluoro-1-NaphtholExperimental Treatment1 Intervention
Participants will receive 1 injection of \[18F\]4FN
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
Trials
3,107
Recruited
1,813,000+
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