Losartan for Arthrofibrosis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing if Losartan, a blood pressure medication, can help reduce scar tissue and stiffness in patients after knee replacement surgery. It aims to improve movement and reduce the need for additional surgeries. Losartan has been studied for various effects including reducing blood pressure and improving heart function.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are already taking an ACE-inhibitor or Angiotensin receptor blocker for hypertension, you cannot participate in this study.
Is losartan generally safe for humans?
How is the drug Losartan unique for treating arthrofibrosis?
Who Is on the Research Team?
Joshua Rozell, MD
Principal Investigator
NYU Langone Health
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-operative Treatment
Participants receive losartan pre-operatively to evaluate its efficacy on range of motion and incidence of manipulation under anesthesia
Post-operative Treatment
Participants continue to receive losartan post-operatively to assess its impact on range of motion and manipulation under anesthesia
Follow-up
Participants are monitored for safety and effectiveness after treatment, focusing on range of motion and manipulation under anesthesia
What Are the Treatments Tested in This Trial?
Interventions
- Losartan
Losartan is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
NYU Langone Health
Lead Sponsor