Eligibility
18+
All Sexes
What conditions do you have?
Select
Study Summary
This trial will test whether losartan can reduce scar tissue formation and improve range of motion following surgery.
Treatment Effectiveness
Effectiveness Progress
This is further along than 93% of similar trials
Study Objectives
2 Primary · 0 Secondary · Reporting Duration: 90 days post-surgery
90 days post-surgery
Post-Operative Range of Motion (ROM)
Post-Operative Rate of Manipulation under Anesthesia (MUA)
Trial Safety
Safety Progress
This is further along than 85% of similar trials
Side Effects for
Usual Treatment
22%Laboratory values outside normal range
19%Psychiatric Hospitalization
7%Medical Hospitalization
2%Completed suicide
1%Diabetes
1%Suicide attempt
Trial Design
2 Treatment Groups
Control Group
1 of 2
Losartan Group
1 of 2
Active Control
Experimental Treatment
380 Total Participants · 2 Treatment Groups
Primary Treatment: Losartan · No Placebo Group · Phase 4
Losartan Group
Drug
Experimental Group · 1 Intervention: Losartan · Intervention Types: DrugControl GroupNoIntervention Group · 1 Intervention: Control Group · Intervention Types:
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Losartan
FDA approved
Trial Logistics
Trial Timeline
Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 90 days post-surgery
Who is running the clinical trial?
NYU Langone HealthLead Sponsor
1,250 Previous Clinical Trials
743,358 Total Patients Enrolled
Joshua Rozell, MDPrincipal InvestigatorNYU Langone Health
Eligibility Criteria
Age 18+ · All Participants · 4 Total Inclusion Criteria
Mark “yes” if the following statements are true for you:Patients are candidates for elective primary total knee arthroplasty for a diagnosis of osteoarthritis or inflammatory arthritis.
About The Reviewer
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
Who else is applying?
What state do they live in?
| Washington | 50.0% |
| Louisiana | 50.0% |
How old are they?
| 65+ | 100.0% |
What site did they apply to?
| NYU Langone Health | 100.0% |
What portion of applicants met pre-screening criteria?
| Met criteria | 50.0% |
| Did not meet criteria | 50.0% |
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