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Radiation Therapy for Metastatic Brain Cancer

Phase 1 & 2

Waitlist Available

Research Sponsored by The Cleveland Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Newly diagnosed supratentorial solitary brain metastasis by enhanced MRI or CT scan

Performance status Karnofsky 70-100%

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial is studying a type of radiation therapy called SRS to see how well it works in treating patients with a brain tumor that has spread.

Who is the study for?

This trial is for adults over 18 with metastatic brain tumors that can be surgically removed. Candidates must have a Karnofsky performance status of 70-100%, indicating they are able to care for themselves, and an expected lifespan of at least three months. They should not have had previous brain radiation therapy or certain chemotherapy treatments for brain metastasis, and cannot be pregnant or nursing.Check my eligibility

What is being tested?

The study is examining the effectiveness of specialized radiation therapy targeted at the area where a metastatic brain tumor has been surgically removed. The goal is to see if this approach effectively kills any remaining cancer cells while minimizing damage to healthy tissue.See study design

What are the potential side effects?

While specific side effects are not listed here, radiation therapy can generally cause fatigue, headaches, scalp irritation, and hair loss in the treated area. It may also lead to short-term memory problems or changes in cognitive function.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have a new single brain tumor identified by MRI or CT scan.

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I am mostly able to care for myself and carry out daily activities.

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I do not have a serious infection.

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I do not have unstable chest pain.

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My blood pressure is under control.

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My condition can be treated with surgery.

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I am 18 years old or older.

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My heart rhythm is stable.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Local control rate as measured by MRI with contrast at 1 year

0 / 8Eligibility criteria met

Find a Location

Who is running the clinical trial?

The Cleveland ClinicLead Sponsor

1,030 Previous Clinical Trials

1,363,956 Total Patients Enrolled

Robert Weil, MDStudy ChairThe Cleveland Clinic

1 Previous Clinical Trials

10 Total Patients Enrolled

Media Library

Treatment Clinical Trial Eligibility Overview. Trial Name: NCT00107367 — Phase 1 & 2

Cancer Clinical Trial 2023: Treatment Highlights & Side Effects. Trial Name: NCT00107367 — Phase 1 & 2

Treatment 2023 Treatment Timeline for Medical Study. Trial Name: NCT00107367 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it feasible to enroll in this study at the present time?

"Clinicaltrials.gov has confirmed that this medical study, first posted on April 1st 2004, is no longer accepting patients. However, there are currently 726 different trials actively searching for participants."

Answered by AI

Recent research and studies

Journal of NeurosurgeryJournal

Intraoperative Radiotherapy to Treat Newly Diagnosed Solitary Brain Metastasis: Initial Experience and Long-term Outcomes

Weil, Robert J., Gaurav G. Mavinkurve, Samuel T. Chao, Michael A. Vogelbaum, John H. Suh, Matthew Kolar, and Steven A. Toms. 2015. “Intraoperative Radiotherapy to Treat Newly Diagnosed Solitary Brain Metastasis: Initial Experience and Long-term Outcomes”. Journal of Neurosurgery. Journal of Neurosurgery Publishing Group (JNSPG). doi:10.3171/2014.11.jns1449.

clinicaltrials.govStudy

Radiation Therapy in Treating Patients Who Are Undergoing Surgery to Remove a Metastatic Brain Tumor

2004. "Radiation Therapy in Treating Patients Who Are Undergoing Surgery to Remove a Metastatic Brain Tumor". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00107367.

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