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Monoclonal Antibodies

Avelumab for Mesothelioma

Phase 1 & 2

Waitlist Available

Led By Andreas Rimner, MD

Research Sponsored by Memorial Sloan Kettering Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 years

Awards & highlights

Study Summary

This trial is testing whether the combination of two cancer treatments, avelumab and SBRT, is safe and effective. It's also looking at how radiation therapy affects the immune system.

Eligible Conditions

Mesothelioma

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Overall Response Rate

Side effects data

From 2020 Phase 2 trial • 19 Patients • NCT03006848

17%

Musculoskeletal and connective tissue disorders

11%

Injury, poisoning and procedural complications

Immune system disorders

Gastrointestinal disorders

Investigations

Infections and infestations

Metabolism and nutrition disorders

General disorders and administration site conditions

Nervous system disorders

Cardiac disorders

Endocrine disorders

Blood and lymphatic system disorders

Neoplasms benign, malignant and unspecified

Respiratory, thoracic and mediastinal disorders

Renal and urinary disorders

Skin and subcutaneous tissue disorders

100%

80%

60%

40%

20%

Study treatment Arm

Avelumab

Trial Design

1Treatment groups

Experimental Treatment

Group I: AvelumabExperimental Treatment2 Interventions

The treatment will consist of one dose of avelumab every other week as well as a short course of SBRT after the first two doses of avelumab.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Stereotactic Body Radiation Therapy

2012

Completed Phase 2

~780

Avelumab

2018

Completed Phase 2

~2450

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor

1,936 Previous Clinical Trials

588,883 Total Patients Enrolled

19 Trials studying Mesothelioma

782 Patients Enrolled for Mesothelioma

PfizerIndustry Sponsor

4,570 Previous Clinical Trials

10,916,011 Total Patients Enrolled

3 Trials studying Mesothelioma

98 Patients Enrolled for Mesothelioma

Andreas Rimner, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

11 Previous Clinical Trials

397 Total Patients Enrolled

3 Trials studying Mesothelioma

105 Patients Enrolled for Mesothelioma

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies for this clinical trial?

"Currently, this trial is not enrolling new participants. Initially posted on December 20th 2017 and last updated March 7th 2022, if you are searching for other studies 1614 trials targeting mesothelioma malignant patients and 112 studies of Avelumab are currently accepting recruits."

Answered by AI

Can you provide an account of the precedential trials for Avelumab?

"Currently, 112 clinical trials are actively investigating the use of Avelumab with 10 being in Phase 3. Although Barcelona and South dakota have the most amount of trials, there is a total of 3685 test locations for this medication worldwide."

Answered by AI

How many research locations are actively conducting this trial?

"Presently, there are 7 participating sites in this medical trial. These include Memorial Sloan Kettering Rockville Centre, MSKCC New york and MSK Basking Ridge among others."

Answered by AI

What is the upper capacity for participants in this trial?

"At this time, no additional participants are being recruited for this trial. The research was initially uploaded on December 20th 2017 and last edited on March 7th 2022. Should you be seeking other studies, 1614 clinical trials related to mesothelioma malignancy and 112 Avelumab-focused investigations are accepting volunteers."

Answered by AI

Is this experiment unprecedented in its scope?

"At present, there are 112 ongoing clinical studies for Avelumab which span 1024 cities and 52 nations. The inaugural trial of this drug was launched by EMD Serono Research & Development Institute Inc., in 2014 with a total of 204 participants. Since then, 66 trials have concluded their Phase 2 approval process."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Stereotactic Body Radiation Therapy and Avelumab Immunotherapy for Treatment of Malignant Mesothelioma

2017. "Stereotactic Body Radiation Therapy and Avelumab Immunotherapy for Treatment of Malignant Mesothelioma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03399552.