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Growth Hormone

IGF-1/IGFBP-3 for Burns

Phase 2 & 3
Waitlist Available
Led By David N. Herndon, MD
Research Sponsored by The University of Texas Medical Branch, Galveston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up admission to burn unit to 95% wound healing
Awards & highlights

Study Summary

The purpose of this study is to find ways to improve wound healing and decrease the negative effects of trauma from burn injury.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~admission to burn unit to 95% wound healing
This trial's timeline: 3 weeks for screening, Varies for treatment, and admission to burn unit to 95% wound healing for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Decrease Hypermetabolism as Measured by Stable Isotope Infusion Study
Secondary outcome measures
Improved Rate of Wound Healing
Incidence of Morbidity and Mortality
Incidence of Sepsis

Trial Design

10Treatment groups
Experimental Treatment
Placebo Group
Group I: PropranololExperimental Treatment2 Interventions
Propranolol administered daily until 95% wound healing Stable Isotope Infusion Study with collection of blood and tissue
Group II: Oxandrolone and PropranololExperimental Treatment2 Interventions
Oxandrolone and Propranolol will be administered until 95% wound healing
Group III: OxandroloneExperimental Treatment2 Interventions
Oxandrolone administered daily until 95% wound healing Stable Isotope Infusion Study with collection of blood and tissue
Group IV: ItraconazoleExperimental Treatment2 Interventions
Itraconazole will be administered until 95% wound healing.
Group V: Insulin Low DoseExperimental Treatment2 Interventions
Insulin Low Dose will be administered until 95% wound healing.
Group VI: Insulin High DoseExperimental Treatment2 Interventions
Insulin IV administered continuously to 95% healing. Stable Isotope Infusion Study with collection of blood and tissue
Group VII: IGF-1/IGFBP-3Experimental Treatment2 Interventions
IGF-1/IGFBP-3 will be administered until 95% wound healing
Group VIII: Growth Hormone and PropranololExperimental Treatment2 Interventions
Growth Hormone and Propranolol will be administered until 95% wound healing.
Group IX: Growth HormoneExperimental Treatment2 Interventions
Growth Hormone administered daily until 95% wound healing. Stable Isotope Infusion Study with collection of blood and tissue
Group X: Control/PlaceboPlacebo Group2 Interventions
Placebo or Control will be administered until 95% wound healing
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Stable Isotope Infusion study
2000
Completed Phase 3
~650
Propranolol
FDA approved
Insulin human
FDA approved
Somatotropin
FDA approved
Somatotropin
FDA approved
Itraconazole
FDA approved
Insulin human
FDA approved
IGF-1/IGFBP-3
2000
Completed Phase 3
~650
Oxandrolone
FDA approved
Propranolol
FDA approved

Find a Location

Who is running the clinical trial?

The University of Texas Medical Branch, GalvestonLead Sponsor
246 Previous Clinical Trials
56,156 Total Patients Enrolled
28 Trials studying Burns
12,680 Patients Enrolled for Burns
National Institute of General Medical Sciences (NIGMS)NIH
271 Previous Clinical Trials
246,376 Total Patients Enrolled
12 Trials studying Burns
3,764 Patients Enrolled for Burns
David N. Herndon, MDPrincipal InvestigatorUniversity of Texas
1 Previous Clinical Trials
1 Trials studying Burns

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Assessment of Mechanisms of Improved Wound Healing
2000. "Assessment of Mechanisms of Improved Wound Healing". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00673309.
~26 spots leftby May 2025
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