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Segmental allergen challenge for Cat Allergy

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Cat Allergy+4 MoreSegmental allergen challenge - Biological
Eligibility
18 - 50
All Sexes
What conditions do you have?
Select

Study Summary

This trial is studying the airway immune response to inhaled allergens in people with and without asthma to see what promotes the disease.

Eligible Conditions
  • Cat Allergy
  • Allergic Eye
  • Dust Mite Allergy
  • Asthma, Allergic
  • Allergy (or Hay Fever)

Treatment Effectiveness

Effectiveness Progress

1 of 3

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Study Objectives

5 Primary · 3 Secondary · Reporting Duration: 18 months

18 months
Antibodies in blood
Antibodies in lung washes
Cytokines
Dendritic cell function
Dendritic cell number and phenotype
Immune composition of the airway
Mediators of organized airway immune tissue formation
Organized airway immune tissue

Trial Safety

Safety Progress

1 of 3

Similar Trials

1
Bronchoscopy, Segmental Allergen Challenge, and Broncheoalveolar Lavage
1
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2
REGN5713-5714-5715

Trial Design

1 Treatment Group

Segmental allergen challenge
1 of 1

Experimental Treatment

12 Total Participants · 1 Treatment Group

Primary Treatment: Segmental allergen challenge · No Placebo Group · Phase 1

Segmental allergen challenge
Biological
Experimental Group · 1 Intervention: Segmental allergen challenge · Intervention Types: Biological

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 18 months

Who is running the clinical trial?

JOSALYN CHOLead Sponsor
Massachusetts General HospitalOTHER
2,698 Previous Clinical Trials
30,843,124 Total Patients Enrolled
Josalyn L Cho, MDPrincipal InvestigatorUniversity of Iowa

Eligibility Criteria

Age 18 - 50 · All Participants · 10 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
Female participants who could potentially become pregnant must agree to use a birth control method that is approved by the FDA for the duration of the study
No positive urine pregnancy tests were detected in any of the female participants who were of reproductive potential.
The text discusses the age range between 18 and 50 years old.
Any person who wishes to take part in the study must be able to understand the information provided about the study and give informed consent.
The patient has a positive skin prick test to the allergen that is causing their clinical symptoms
I have not vaped, inhaled, or smoked any non-cigarette products in the past year.
An allergic reaction to cats that leads to symptoms such as eye watering, itching, and swelling.
The clinical history of asthma is characterized by episodes of wheezing, chest tightness, and shortness of breath
This individual has never smoked cigarettes for a total of 10 packs over the course of their life, and haven't smoked in the past year.
References

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