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Preoperative Embolization for Head and Neck Cancers

Phase 1
Waitlist Available
Led By Melanie Walker
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up directly after the embolization
Awards & highlights

Study Summary

This trial will test whether embolization done prior to surgery will improve surgical outcomes in head and neck tumors with large amounts of blood vessels.

Eligible Conditions
  • Head and Neck Cancer
  • Head and Neck Cancers

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~directly after embolization and for 24 hours post-embolization
This trial's timeline: 3 weeks for screening, Varies for treatment, and directly after embolization and for 24 hours post-embolization for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Intraoperative blood loss
Secondary outcome measures
Adverse events (AE) related to angiography or embolization
Perioperative blood transfusion volume
Success of embolization
+1 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment (PVA, EOV, tumor vessel embolization)Experimental Treatment7 Interventions
Patients receive iodixanol via injection and undergo diagnostic cerebral angiogram over 30 minutes. If the tumor blood supply is suitable, patients undergo tumor vessel embolization with PVA suspended in EOV and delivered via a catheter. Patients also undergo head and neck CT scans immediately after completion of tumor vessel embolization, and again between 2-3 months later.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Angiogram
2021
Completed Early Phase 1
~10
Arterial Embolization
2016
Completed Phase 2
~10
Computed Tomography
2017
Completed Phase 2
~2720

Find a Location

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,738 Previous Clinical Trials
1,844,351 Total Patients Enrolled
GuerbetIndustry Sponsor
68 Previous Clinical Trials
93,722 Total Patients Enrolled
Melanie WalkerPrincipal InvestigatorFred Hutch/University of Washington Cancer Consortium

Media Library

Angiogram Clinical Trial Eligibility Overview. Trial Name: NCT05490381 — Phase 1
Angiogram 2023 Treatment Timeline for Medical Study. Trial Name: NCT05490381 — Phase 1
Head and Neck Cancers Research Study Groups: Treatment (PVA, EOV, tumor vessel embolization)
Head and Neck Cancers Clinical Trial 2023: Angiogram Highlights & Side Effects. Trial Name: NCT05490381 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the requirements to take part in this research experiment?

"This clinical trial seeks 20 participants with malignant neoplasms aged between 18 and 80. To be eligible, they must have a blood supply from the external carotid artery, intend to undertake surgical resection of their tumors, meet imaging requirements through MRI or CT scans, may have prior therapies under their belt; adults within the specified age range are also required with a minimum life expectancy period of 3 months. Moreover, applicants need an eGFR above 30 mL/min/1.73 m^2 not being pregnant at angiographic intervention and having extra-axial head & neck tumours greater than 2 cm in size."

Answered by AI

Does this medical trial admit seniors over the age of 65?

"This trial only allows people aged 18 to 80, with 315 studies catering towards minors and 2,553 targeting patients over the age of 65."

Answered by AI

What is the maximum capacity of participants enrolled in this research?

"Affirmative. The information listed on clinicaltrials.gov discloses that this research is actively searching for participants who meet the eligibility criteria. This trial was initially posted in December 1, 2022 and recently updated in November 4, 2022; a total of 20 patients are needed from one medical center to participate."

Answered by AI

Is this clinical trial open to new participants at the moment?

"Affirmative. Clinicaltrials.gov's records demonstrate that this clinical trial, which was initially made available on December 1st 2022, is currently recruiting participants. The study requires 20 patients to be recruited from only one medical centre."

Answered by AI

Has Angiogram been endorsed by the FDA?

"This experimental drug has been assigned a rating of 1, as there is only limited evidence regarding its safety and effectiveness."

Answered by AI
~0 spots leftby Jan 2025