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MRI Imaging Techniques for Brain Arteriovenous Malformations

Q: Is recruitment for this clinical trial still active?

<p>Affirmative. According to the information posted on clinicaltrials.gov, this medical trial is looking for 12 patients from a single location and was first shared in March 2020 before being updated recently in June 2022.</p>

Q: How many participants are permitted to join this clinical research project?

<p>That is correct. Information found on clinicaltrials.gov indicates that this medical trail, which was initially posted on March 1st 2020, continues to search for participants. The research requires 12 patients from 1 centre to be recruited.</p>

N/A

Recruiting

Led By Daniela Iancu, MD

Research Sponsored by Ottawa Hospital Research Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Brain AVMs previously diagnosed with either CT Angiography, MRI or catheter angiography

mRS <=2

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 months

Awards & highlights

Study Summary

This trial is studying how well endovascular embolization works compared to surgery in treating brain arteriovenous malformations.

Who is the study for?

This trial is for adults over 18 with brain arteriovenous malformations (AVMs) visible on MRI, specifically where the abnormal tangle of arteries measures more than 1 cm. Participants must be able to give informed consent, have a minor or no disability from their condition (mRS <=2), and are scheduled for cerebral catheter angiography. Those with non-MRI compatible implants, severe claustrophobia, kidney issues (GFR < 60 ml/min), or contrast allergies cannot join.Check my eligibility

What is being tested?

The study tests advanced MRI techniques like susceptibility-weighted imaging and time-resolved magnetic resonance angiography in patients with brain AVMs. These methods aim to provide detailed images of blood flow in the brain to help plan treatments that prevent bleeding or other neurological symptoms without harming normal brain function.See study design

What are the potential side effects?

Since this trial involves MRI scans which are generally safe and non-invasive, side effects are rare but may include discomfort from lying still during the scan or reactions to contrast agents used if applicable.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My brain AVM was confirmed by a CT, MRI, or catheter angiography.

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I can carry out all my usual duties with minimal help.

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I am scheduled for a special brain scan to check for abnormal blood vessels.

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I am older than 18 years.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Angiogram

Trial Design

1Treatment groups

Experimental Treatment

Group I: MRI perfusion imagingExperimental Treatment1 Intervention

SWAN imaging on the GE 3 T has been attempted but the preliminary evidence suggest that the images are of low resolution and difficult to interpret. Similarly, early experience with TRMRA suggest poor spatial and temporal resolution using the standard "out-of-the-box" protocols. Thus, there is a significant opportunity to improve SWAN and TRMRA, to evaluate the evolution of progressive obliteration of the AVM nidus. Specifically, this is attractive for brain AVMs that are treated with radiosurgery as MRI is required for clinical grounds for treatment planning purposes.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

MRI perfusion imaging

2018

N/A

~40

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Ottawa Hospital Research InstituteLead Sponsor

561 Previous Clinical Trials

2,785,482 Total Patients Enrolled

Daniela Iancu, MDPrincipal InvestigatorOttawa Hospital Research Institute

2 Previous Clinical Trials

340 Total Patients Enrolled

Howard Lesiuk, MDPrincipal InvestigatorOttawa Hospital Research Institute

Media Library

Endovascular Embolization Clinical Trial Eligibility Overview. Trial Name: NCT03031873 — N/A

Arteriovenous Malformations Research Study Groups: MRI perfusion imaging

Arteriovenous Malformations Clinical Trial 2023: Endovascular Embolization Highlights & Side Effects. Trial Name: NCT03031873 — N/A

Endovascular Embolization 2023 Treatment Timeline for Medical Study. Trial Name: NCT03031873 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is recruitment for this clinical trial still active?

"Affirmative. According to the information posted on clinicaltrials.gov, this medical trial is looking for 12 patients from a single location and was first shared in March 2020 before being updated recently in June 2022."

Answered by AI

How many participants are permitted to join this clinical research project?

"That is correct. Information found on clinicaltrials.gov indicates that this medical trail, which was initially posted on March 1st 2020, continues to search for participants. The research requires 12 patients from 1 centre to be recruited."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Evaluation of Susceptibility-weighted Magnetic Resonance Imaging and 4d-time-resolved Magnetic Resonance Angiography in Brain Arteriovenous Malformations

2020. "Evaluation of Susceptibility-weighted Magnetic Resonance Imaging and 4d-time-resolved Magnetic Resonance Angiography in Brain Arteriovenous Malformations". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03031873.