Genicular Artery Embolization for Knee Osteoarthritis
Trial Summary
Do I have to stop taking my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications. However, since the trial includes patients who have tried anti-inflammatory medications, it seems you may continue them.
What data supports the idea that Genicular Artery Embolization for Knee Osteoarthritis is an effective treatment?
The available research shows that Genicular Artery Embolization (GAE) is considered a promising treatment for knee osteoarthritis. Studies have investigated its effectiveness in reducing chronic pain associated with the condition. A systematic review and meta-analysis highlighted in the research suggests that GAE can be a supplementary method to alleviate knee pain caused by osteoarthritis. This indicates that GAE may be a beneficial option for those seeking relief from knee osteoarthritis symptoms.12345
What safety data is available for Genicular Artery Embolization in treating knee osteoarthritis?
The safety of Genicular Artery Embolization (GAE) for knee osteoarthritis has been evaluated in several studies. The study titled 'Genicular Artery Embolization for the Treatment of Symptomatic Knee Osteoarthritis' specifically assesses the safety and efficacy of GAE. Additionally, systematic reviews and meta-analyses, such as those in 'Genicular Artery Embolization as a Treatment for Osteoarthritis Related Knee Pain' and 'Osteoarthritis-Related Knee Pain Treated With Genicular Artery Embolization,' provide comprehensive evaluations of existing evidence on the safety and effectiveness of GAE for knee OA.13456
Is Genicular Artery Embolization a promising treatment for knee osteoarthritis?
Yes, Genicular Artery Embolization (GAE) is a promising treatment for knee osteoarthritis. It is a new and innovative method that has shown potential in reducing knee pain associated with osteoarthritis. GAE is minimally invasive, meaning it doesn't require large incisions, and it targets the blood vessels in the knee to help manage pain.12346
What is the purpose of this trial?
The objective of this investigation is to evaluate the safety of the geniculate artery embolization (GAE) procedure with HydroPearl® Microspheres in 30 patients with knee pain caused by osteoarthritis with 24 months follow-up. The GAE procedure is an arterial embolization procedure that blocks abnormal blood vessels caused be knee arthritis in order to evaluate the effect on knee pain.
Research Team
Andrew Picel, MD
Principal Investigator
Stanford University
Eligibility Criteria
This trial is for adults over 40 with moderate to severe knee pain due to osteoarthritis, who haven't found relief from anti-inflammatory meds, physical therapy, or injections. They should have certain MRI features of active synovitis and not be candidates for surgery. People with life-threatening allergies to iodine, recent major knee surgeries (except minor arthroscopic), serious coagulation issues, kidney problems or other types of arthritis are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo the genicular artery embolization (GAE) procedure with HydroPearl® Microspheres
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Genicular Artery Embolization (GAE)
Genicular Artery Embolization (GAE) is already approved in United States, European Union for the following indications:
- Osteoarthritic knee pain
- Pain from osteoarthritis of the knee not responsive to conservative treatment
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Who Is Running the Clinical Trial?
Andrew Picel
Lead Sponsor