Allulose for Calorie Burning

Overseen By Nick Bellissimo

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Toronto Metropolitan University

Disqualifiers: Diabetes, Pregnancy, Gastrointestinal, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

Duration: 3 days

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how different doses of allulose, a sugar substitute, can help burn calories, affect blood sugar, and influence hunger levels. It targets healthy adults who do not smoke and have a normal weight, defined as a body mass index (BMI) between 20 and 24.9. Participants should not have conditions like diabetes or recent major medical events and should not be on a diet or skip breakfast. As an unphased trial, this study provides a unique opportunity to contribute to scientific knowledge about allulose and its potential health benefits.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it excludes those who have taken medication that could affect metabolism or intake regulation.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research shows that allulose is generally safe for people. The U.S. Food and Drug Administration (FDA) has approved it and considers it "generally recognized as safe" (GRAS). Studies suggest that allulose can help reduce weight gain and improve insulin handling, especially with diets high in fat and sugar. This means allulose might aid in weight management without causing major side effects.

In studies with healthy people, allulose was well-tolerated. It tastes like regular sugar but lacks many negative effects. It has zero net carbs and very few calories, which benefits those watching their sugar intake. Overall, while allulose appears safe, staying informed and consulting a healthcare provider before trying something new is always wise. ^{1 2 3 4 5}

Why are researchers excited about this trial's treatments?

Researchers are excited about Allulose for calorie burning because it offers a unique approach compared to traditional weight loss methods like diet and exercise. Allulose is a low-calorie sweetener that has the potential to increase calorie burning by influencing metabolism differently than other sweeteners and weight loss supplements. Unlike typical treatments that focus on reducing calorie intake, Allulose may help the body burn more calories, providing a potential new tool for managing weight. Its ability to act as a sweetener while also promoting calorie burning makes it a promising candidate for those looking to manage their weight more effectively.

What evidence suggests that allulose could be effective for calorie burning?

Research has shown that allulose can help lower body fat and improve insulin handling. In one study, participants who took allulose for 12 weeks lost body fat. Another study found that allulose prevented weight gain, even with a high-fat, high-sugar diet. Allulose also appears to increase fat burning after meals, which may aid in weight control. These findings suggest that allulose could help burn more calories and manage body weight. Participants in this trial will receive different doses of allulose to evaluate its effectiveness in calorie burning and weight management. ^{2 4 5 6 7}

Who Is on the Research Team?

Nick Bellissimo

Principal Investigator

Toronto Metropolitan University

Are You a Good Fit for This Trial?

Healthy adults aged 18-45, non-smokers with a normal weight BMI (20-24.9 kg/m2), can join this trial. Those with diabetes, gastrointestinal, liver or kidney disease, on conflicting diets or medications affecting metabolism and intake regulation, pregnant or possibly pregnant women, allergic to test ingredients, unable to complete tests, having high fasting glucose levels or recent major medical events are excluded.

Inclusion Criteria

I am 18-45 years old, healthy, don't smoke, and have a normal BMI.

Exclusion Criteria

Participants with previously diagnosed diabetes

I have a gastrointestinal condition.

Participants who were or are on a diet that may confound the study

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants consume varying doses of allulose on 3 separate days with energy expenditure and glucose monitoring

3 days

3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

1 week

What Are the Treatments Tested in This Trial?

Interventions

• Allulose

Trial Overview

The study is testing how different doses of allulose affect the body's heat production after eating (diet-induced thermogenesis), fat and sugar burning rates (substrate oxidation), blood sugar levels (glycemic response), and feelings of hunger in healthy individuals.

How Is the Trial Designed?

Group I: Allulose Dose 3 Experimental Treatment 1 Intervention

Treatment

Group II: Allulose Dose 2 Experimental Treatment 1 Intervention

Treatment

Group III: Allulose Dose 1 Experimental Treatment 1 Intervention

Treatment

Who Is Running the Clinical Trial?

Toronto Metropolitan University

Lead Sponsor

Trials

95

Recruited

19,300+

Anderson Advanced Ingredients

Industry Sponsor

Trials

2

Recruited

30+

Citations

1.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC5852736/

A Preliminary Study for Evaluating the Dose-Dependent Effect ...

However, in the present study with human subjects, d-allulose supplementation for 12 weeks reduced body fat mass, body fat percentage, and subcutaneous fat (SAT) ...

2.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC11207032/

The Metabolic and Endocrine Effects of a 12-Week Allulose ...

Our results showed that allulose mitigated the adverse effects of high-fat, high-sugar diets, including reduced body weight gain and improved insulin resistance ...

3.

clinicaltrials.gov

clinicaltrials.gov/study/NCT02988999?intr=erythritol&rank=8

Efficacy of D-allulose on Weight and Fat Loss and Insulin ...

Body weight change after 24 weeks of D-allulose consumption to erythritol consumption, 28 weeks (assess 4 weeks after 24 weeks consumption of the study product).

4.

sciencedirect.com

sciencedirect.com/science/article/abs/pii/S0899900717301181

d-Allulose enhances postprandial fat oxidation in healthy ...

To our knowledge, the present study showed for the first time that d-allulose increased fat oxidation and decreased carbohydrate oxidation in healthy humans.

5.

levels.com

levels.com/blog/levels-guide-allulose

The 2025 Levels Guide to allulose and its effects in your body

Preliminary research suggests that allulose may support fat loss, particularly abdominal fat reduction, by enhancing fat oxidation and ...

6.

fda.gov

fda.gov/media/123342/download

Guidance for Industry: The Declaration of Allulose and ...

In a comment to the Tate & Lyle citizen petition, the Food Lawyers stated that they fully supported a caloric value for allulose of 0.2 kcal/g.

7.

health.clevelandclinic.org

health.clevelandclinic.org/what-is-allulose

Allulose: What It Is and Side Effects

Is allulose safe? Allulose is approved by the U.S. Food and Drug Administration (FDA), which considers it “generally recognized as safe” (GRAS).