A2530 for Colorectal Cancer

Phase-Based Progress Estimates
City of Hope, Duarte, CAColorectal Cancer+13 MoreA2B530 - Biological
All Sexes
What conditions do you have?

Study Summary

This trial will test a new therapy, A2B530, on different types of solid tumors. Participants will receive treatments and assessments.

Eligible Conditions
  • Colorectal Cancer
  • Pancreatic Cancer
  • Solid Tumors, Adult
  • Solid Tumors
  • Non-Small Cell Lung Cancer
  • Non-small Cell Lung Cancer (NSCLC), Recurrent
  • Non-Small Cell Squamous Lung Cancer
  • Non-Small Cell Lung Cancer, Recurrent
  • Metastatic Colorectal Cancer
  • Cancer

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

3 Primary · 2 Secondary · Reporting Duration: From the time of Informed consent until 24 months (2 years) post A2B530 infusion.

Day 21
Phase 1: Recommended Phase 2 Dose (RP2D)
Month 24
Phase 2: The Overall Response Rate (ORR) for patients
Year 2
Phase 1: Rate of adverse events and dose limiting toxicities (DLTs) by dose level
Month 24
Cytokine analysis
Persistence of A2B530

Trial Safety

Safety Progress

1 of 3

Trial Design

1 Treatment Group

1 of 1

Experimental Treatment

160 Total Participants · 1 Treatment Group

Primary Treatment: A2530 · No Placebo Group · Phase 1 & 2

A2530Experimental Group · 2 Interventions: A2B530, xT-Onco with HLA-LOH Assay · Intervention Types: Biological, DiagnosticTest

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: from the time of informed consent until 24 months (2 years) post a2b530 infusion.

Who is running the clinical trial?

A2 Biotherapeutics Inc.Lead Sponsor
1 Previous Clinical Trials
200 Total Patients Enrolled
Tempus LabsIndustry Sponsor
11 Previous Clinical Trials
6,155 Total Patients Enrolled
Eric Ng, MDStudy DirectorSr. Medical Director, Safety, A2 Biotherapeutics, Inc.

Eligibility Criteria

Age 18+ · All Participants · 7 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are expected to live for at least three more months.

Frequently Asked Questions

Are there any American locations in which this trial is currently being conducted?

"Currently, 7 different cities are hosting this trial. These locations include Los Angeles, Jacksonville and Tampa in addition to 4 other locales; it is recommended that study participants select the nearest site for their convenience." - Anonymous Online Contributor

Unverified Answer

Are there any vacancies still available for participants in this research?

"As evidenced by the clinicaltrials.gov listing, this medical investigation is not currently recruiting participants - a status which was verified on February 10th 2023. Despite that, there are 7154 other trials actively seeking subjects at present." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.