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Proton vs Photon Radiation for Meningeal Carcinomatosis
Study Summary
This trial is studying proton craniospinal radiation therapy to see if it is more effective than partial photon radiation therapy in preventing leptomeningeal metastasis from worsening.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- My blood tests show normal levels of hemoglobin, neutrophils, and platelets.My cancer has spread to the lining of my brain and spinal cord.I've had radiation before where they now want to treat, and can't have more without risking harm.I am not pregnant and agree to use birth control during the study.I am a candidate for radiation therapy to treat cancer spread to the lining of my brain and spinal cord.I am over 16 and can care for myself most of the time.My age does not limit my participation.My cancer has spread widely and I have no standard treatment options left.
- Group 1: Standard of Care
- Group 2: Proton CSI Followed by Standard of Care (Other Solid Tumors)
- Group 3: Proton CSI Followed by Standard of Care (NSCLC & Breast)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is enrolment for this research program still accepting participants?
"From what is stated on clinicaltrials.gov, this trial has stopped recruiting candidates. Despite the closure of recruitment for this particular study, there are 640 other medical trials looking to enrol patients at present."
Is Proton Craniospinal Irradiation (CSI) a reliable procedure with minimal risk to patients?
"The safety of Proton Craniospinal Irradiation (CSI) was rated a 2 on the 1-3 scale due to the Phase 2 nature of this trial, which has some evidence supporting its safety but none suggesting efficacy."
Which venues are currently hosting this research endeavor?
"Presently, 10 clinical trial sites are hosting this study. These locations span from Basking Ridge to Harrison and Middletown amongst other cities. Therefore, it is paramount that prospective participants select the closest site in order to mitigate their transit requirements."
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