This trial is evaluating whether Bevacizumab will improve 1 primary outcome and 1 secondary outcome in patients with Cancer. Measurement will happen over the course of Continuous assessment during each dose level/28-day cycle.
This trial requires 218 total participants across 1 different treatment group
This trial involves a single treatment. Bevacizumab is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
"Around 1.2 million people will be diagnosed with a form of cancer in the United States this year. Around 200,000 people will die, and this number will increase. Around 80% will be diagnosed with a form of cancer related to smoking. Around 65% will be diagnosed with breast cancer, and around 30% will be diagnosed with lung cancer. Around 80% will be diagnosed with cancer related to tobacco. Between 30% and 50% will die from cancer. Diabetes is affecting 3 million people, and this number is expected to double over the next 20 years. Around 1.2 million American children will be diagnosed with cancer in the year 2002. Most children will live to be 80 years or older." - Anonymous Online Contributor
"The first cancer cure is not yet on the way. But progress has been made with chemotherapy and radiation therapy. More importantly, most malignancies are now curable by these more aggressive approaches to treatment rather than relying on alternative or complementary approaches. However, a cure for cancer is still a long way ahead." - Anonymous Online Contributor
"Common treatments of cancer include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy. There is no cure for cancer. Treatment must be tailored to the tumor type and the patient's overall health." - Anonymous Online Contributor
"Most cancers are caused in one of several ways, which can be grouped into six main causes for common cancers in adults, namely infections, dietary deficiency deficiencies, pollution, tobacco smoking, excessive use of alcohol and drug misuse. The main causes for many of the diseases are quite complex and include many other factors such as genetics and the environment in which a person lives." - Anonymous Online Contributor
"Cancer is an abnormal growth of cells in the body which reproduce itself but do not die. More than 100,000 people are diagnosed with cancer each year in the UK.\n" - Anonymous Online Contributor
"Skin changes were mostly skin nodules, and may be a sign of cancer or any cutaneous irritation. The signs of cancer are usually limited to localized or localized metastatic lesions, that can be palpated, palpated, or detected through imaging or through laboratory tests and not necessarily by physical examination of the body surface." - Anonymous Online Contributor
"There is growing awareness that bevacizumab may trigger dermatologic reactions in 10-30% of patients undergoing it. Allergic reactions involving the skin are the most common, but rarely severe (e.g. angioedema, blistering, anaphylaxis). Most commonly seen dermatologic events were pruritic erythema and folliculitis. Most patients had only one dermatologic event (primarily pruritus), and all events occurred within 90 days of initiating bevacizumab treatment. Only 6% of patients complained of itching, the least common event. A causal relationship between the drug and the dermatologic symptoms is unclear." - Anonymous Online Contributor
"Adverse effects with and without treatment were manageable with either observation or topical corticosteroids. Treatment may enhance the risk of thrombocytopenia and may increase the risk of hypersensitivity reactions when compared with observation only. The safety and acceptable risks of bevacizumab therapy in this population appears to be similar to what has been shown in the treatment of non-curative malignancies." - Anonymous Online Contributor
"This preliminary study identified potential candidates/contraindications for enrollment into cancer clinical trials, highlighting the need for a standard checklist to help clinicians identify patients who are/are not eligible for clinical trials. Such a checklist could also help clinicians determine which patients have the highest likelihood of benefit from clinical trial enrollment." - Anonymous Online Contributor
"Primary cancer causes are not things like smoking and air pollution like these cause lung cancer specifically, they may include things such as viruses, bacteria, and so on. They are also not things like alcohol like this can cause a type of cancer, most people in this situation would probably do better with a primary prevention approach to get their cancer under control, not just dealing with it after it has happened." - Anonymous Online Contributor
"Recently a large trial of bevacizumab with a large number of patients has been published showing a benefit in metastatic disease. This is the first large study of bevacizumab therapy in patients with metastatic disease. Although this study was not randomized, it showed some strong evidence suggesting that bevacizumab may be a useful treatment. However, in patients at high risk of death it should be used with skepticism. Other ongoing clinical trials are comparing bevacizumab to placebo in the metastatic setting." - Anonymous Online Contributor
"The incidence of cancer in England and Wales and Northern Ireland has continued to rise as of the year, which is projected to increase, there have been no significant decreases in mortality rates. Currently available methods for diagnosing cancer with any degree of certainty will continue to advance. In addition, the ability to accurately categorise the patient in terms of cancer type, grade, and treatment response will be made easier." - Anonymous Online Contributor