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Nicotinamide Riboside for Ulcerative Colitis
Study Summary
This trial is testing if a supplement called NR can help treat UC in children. It's a small study, and NR hasn't been tested in this way before.
Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have kidney or liver problems.My condition is diagnosed as indeterminate colitis or IBD-U.I am not pregnant and will use contraception if of childbearing age.I have severe ulcerative colitis.I do not have an ongoing infection in my digestive system.I have taken steroids or antibiotics in the last 3 months.I have been diagnosed with Crohn's disease.My platelet count is above 50,000.I am 18 years old or younger.I have been diagnosed with mild to moderate ulcerative colitis.I have a chronic inflammatory or autoimmune disorder, or a history of another cancer.My biologic medication dose has been stable for 3 months.
- Group 1: Daily oral therapy with placebo + Standard Therapy
- Group 2: Daily oral therapy with Nicotinamide Riboside Chloride (Niagen) + Standard Therapy
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
To what extent does this trial aim to yield a result?
"The purpose of this trial, assessed over a two-year period, is to gauge the rate of participant enrollment. Additionally, changes in PGC1α and Sirt1 levels will be monitored using western blotting and qRT-PCR analysis; scanning electron microscopy or immunofluorescence imaging will track alterations in mitochondrial structure; finally, an untargeted metabolomic analysis of intestinal epithelium cells shall measure cellular metabolism at baseline and 6-12 months post treatment."
Are there any signup opportunities for this clinical research study?
"Based on data hosted on clinicaltrials.gov, this trial has ceased recruitment activities; the study was launched in January 1st 2023 and last updated October 7th 2022. Nevertheless, there are currently 408 other medical studies actively enrolling patients."
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