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Alkylating agents

A for Non-Small Cell Lung Cancer

Phase < 1
Waitlist Available
Research Sponsored by The Cooper Health System
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4-6 months
Awards & highlights

Study Summary

This is a pilot study looking at using stereotactic radiosurgery and full dose chemotherapy to treat stage II and III lung cancer that is not amendable to surgical resection.

Eligible Conditions
  • Non-Small Cell Lung Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4-6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4-6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Disease free progression
Toxicity (Treatment related side effects)

Trial Design

1Treatment groups
Experimental Treatment
Group I: AExperimental Treatment6 Interventions
Chemotherapy: for Non-Squamous Cell: Pemetrexed 500 mg/m2 and cisplatin 75 mg/m2 on day 1 of 21 day cycle or Carboplatin AUC6 and Paclitaxel 75 mg/m2 on day 1 of 21 day cycle for Squamous Cell: Cisplatin 75 mg/m2 and docetaxel 75mg m2 day 1 of 21 day cycle or Carboplatin AUC6 and paclitaxel 200 mg/m2 day 1 of 21 day cycle Radiation- Stereotactic radiosurgery Peripheral Lung lesion: 60 Gy over 3 fractions Central Lung lesion: 50 Gy over 5 fractions Hilar and Mediastinal LNs 40-50Gy over 5 fractions Schedule is: 2 cycles of chemotherapy, followed by SRS, followed by 2 additional cycles of chemotherapy.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Docetaxel
FDA approved
Paclitaxel
FDA approved
stereotactic radiosurgery
2011
Completed Phase 3
~1000
Pemetrexed
FDA approved
Carboplatin
FDA approved
Cisplatin
FDA approved

Find a Location

Who is running the clinical trial?

The Cooper Health SystemLead Sponsor
75 Previous Clinical Trials
24,091 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Stereotactic Radiosurgery and Systemic Dose Chemotherapy for Locally Advanced Lung Cancer
2013. "Stereotactic Radiosurgery and Systemic Dose Chemotherapy for Locally Advanced Lung Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02568033.
All > Sbrt
~2 spots leftby Apr 2025
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