Nitric Oxide for Chronic Obstructive Pulmonary Disease (COPD)

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Chronic Obstructive Pulmonary Disease (COPD)Nitric Oxide - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether reducing dead space with a pulmonary vasodilator (inhaled nitric oxide) can improve symptoms of breathlessness during exercise in patients with mild COPD.

Eligible Conditions
  • Chronic Obstructive Pulmonary Disease (COPD)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

2 Primary · 5 Secondary · Reporting Duration: At 4 minutes from start of exercise

At 4 minutes from start of exercise
Dyspnea Intensity
Esophageal Pressure (Pes)
Gastric Pressure (Pga)
Inspiratory neural drive
Lung volumes
Metabolic and gas exchange
Trans-diaphragmatic Pressure (Pdi)

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Inhaled Nitric Oxide
1 of 2
Placebo
1 of 2

Experimental Treatment

Non-Treatment Group

20 Total Participants · 2 Treatment Groups

Primary Treatment: Nitric Oxide · Has Placebo Group · Phase < 1

Inhaled Nitric Oxide
Drug
Experimental Group · 1 Intervention: Nitric Oxide · Intervention Types: Drug
Placebo
Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nitric Oxide
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: at 4 minutes from start of exercise

Who is running the clinical trial?

Queen's UniversityLead Sponsor
336 Previous Clinical Trials
110,928 Total Patients Enrolled
15 Trials studying Chronic Obstructive Pulmonary Disease (COPD)
909 Patients Enrolled for Chronic Obstructive Pulmonary Disease (COPD)
Denis E O'Donnell, MDPrincipal InvestigatorQueen's University, Respiratory Investigation Unit
6 Previous Clinical Trials
128 Total Patients Enrolled
3 Trials studying Chronic Obstructive Pulmonary Disease (COPD)
48 Patients Enrolled for Chronic Obstructive Pulmonary Disease (COPD)

Eligibility Criteria

Age 18+ · All Participants · 5 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
People who have smoked for at least 20 pack years are current or ex-smokers.
A person who is male or female and is at least 45 years old.
Mild COPD refers to shortness of breath that is reported by the individual as >=3 on the Medical Research Council dyspnea scale and an FEV1 that is >=80 percent of predicted and a FEV1/FVC ratio that is <0.7 and <LLN.
The subject was able to complete all study procedures and provide/sign informed consent.
The patient is clinically stable if they have a stable hemodynamic status, they are taking the same medications as they were 6 weeks ago, and they have not been admitted to the hospital in the last 6 weeks.