← Back to Search

Pulmonary Vasodilator

Nitric Oxide for Chronic Obstructive Pulmonary Disease

Q: What objectives is this investigation attempting to accomplish?

The main evaluation of this research will focus on the severity of dyspnea experienced four minutes after beginning physical exercise. Furthermore, gastric pressure (Pga), trans-diaphragmatic pressure (Pdi) and metabolic gas exchange metrics (to be collected from earlobe blood samples) at peak exertion time are also secondary objectives to be monitored.

Q: What is the current enrollment rate of this research endeavor?

Affirmative. The details posted on clinicaltrials.gov validate that this medical investigation is actively seeking participants, with the initial posting being made on September 1st 2021 and the most recent update occurring 8 days later. This experiment is looking for 20 volunteers at one centre.

Q: Have there been prior experiments leveraging Nitric Oxide?

Currently, there are 21 clinical trials for Nitric Oxide in operation; 8 of which have progressed to Phase 3. Although Shreveport, <a href="https://www.withpower.com/clinical-trials/louisiana">Louisiana</a> is the primary study location, 97 other sites are conducting research on this medication.

Q: Are there current opportunities to enroll in this trial?

In keeping with the information provided on clinicaltrials.gov, this clinical trial is currently recruiting patients. The study was initially launched on September 1st 2021 and has been updated most recently on September 8th 2022.

Phase < 1

Waitlist Available

Led By Denis E O'Donnell, MD

Research Sponsored by Dr. Denis O'Donnell

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at 4 minutes from start of exercise

Awards & highlights

Study Summary

This trial is testing whether reducing dead space with a pulmonary vasodilator (inhaled nitric oxide) can improve symptoms of breathlessness during exercise in patients with mild COPD.

Eligible Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at 4 minutes from start of exercise

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at 4 minutes from start of exercise

This trial's timeline: 3 weeks for screening, Varies for treatment, and at 4 minutes from start of exercise for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Dyspnea Intensity

Inspiratory neural drive

Secondary outcome measures

Esophageal Pressure (Pes)

Gastric Pressure (Pga)

Lung volumes

+2 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Inhaled Nitric OxideExperimental Treatment1 Intervention

Inhaled nitric oxide administered throughout 4 min exercise protocol at 800 ppm.

Group II: PlaceboPlacebo Group1 Intervention

Inhaled room air administered throughout 4 min exercise protocol at FiO2 = 0.21.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Nitric Oxide

FDA approved

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Dr. Denis O'DonnellLead Sponsor

6 Previous Clinical Trials

224 Total Patients Enrolled

Queen's UniversityLead Sponsor

365 Previous Clinical Trials

120,404 Total Patients Enrolled

Denis E O'Donnell, MDPrincipal InvestigatorQueen's University, Respiratory Investigation Unit

6 Previous Clinical Trials

132 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What objectives is this investigation attempting to accomplish?

"The main evaluation of this research will focus on the severity of dyspnea experienced four minutes after beginning physical exercise. Furthermore, gastric pressure (Pga), trans-diaphragmatic pressure (Pdi) and metabolic gas exchange metrics (to be collected from earlobe blood samples) at peak exertion time are also secondary objectives to be monitored."

Answered by AI

What is the current enrollment rate of this research endeavor?

"Affirmative. The details posted on clinicaltrials.gov validate that this medical investigation is actively seeking participants, with the initial posting being made on September 1st 2021 and the most recent update occurring 8 days later. This experiment is looking for 20 volunteers at one centre."

Answered by AI

Have there been prior experiments leveraging Nitric Oxide?

"Currently, there are 21 clinical trials for Nitric Oxide in operation; 8 of which have progressed to Phase 3. Although Shreveport, Louisiana is the primary study location, 97 other sites are conducting research on this medication."

Answered by AI

Are there current opportunities to enroll in this trial?

"In keeping with the information provided on clinicaltrials.gov, this clinical trial is currently recruiting patients. The study was initially launched on September 1st 2021 and has been updated most recently on September 8th 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

The Effect of Inhaled Nitric Oxide on Deadspace in COPD

Dr. Denis O'Donnell 2021. "The Effect of Inhaled Nitric Oxide on Deadspace in COPD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04069052.