← Back to Search

Vasodilator

Inhaled Nitric Oxide for Shortness of Breath

N/A

Waitlist Available

Led By Denis E O'Donnell, MD

Research Sponsored by Queen's University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at isotime (maximum exercise time achieved by all participants during a standard cpet) from baseline (rest) up to 20 minutes.

Awards & highlights

Study Summary

This trial will study the effects of inhaled nitric oxide in patients with post-PE syndrome, specifically those with chronic thromboembolic disease or post-PE related breathlessness.

Eligible Conditions

Shortness of Breath
Pulmonary Embolism

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at isotime (maximum exercise time achieved by all participants during a standard cpet) from baseline (rest) up to 20 minutes.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at isotime (maximum exercise time achieved by all participants during a standard cpet) from baseline (rest) up to 20 minutes.

This trial's timeline: 3 weeks for screening, Varies for treatment, and at isotime (maximum exercise time achieved by all participants during a standard cpet) from baseline (rest) up to 20 minutes. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Dyspnea Intensity

Inspiratory Neural Drive (IND) as measured by Diaphragmatic electromyography (EMGdi)

Leg discomfort Intensity

Secondary outcome measures

Carbon Dioxide Output (VECO2)

Exercise Endurance Time

Inspiratory Capacity

+5 more

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Inhaled Nitric OxideActive Control1 Intervention

Inhaled 40 ppm nitric oxide from a KINOX™ gas cylinder system (Air Liquid Healthcare, Montreal, Quebec, Canada; Control # 198879, DIN 02451328).

Group II: Placebo ControlPlacebo Group1 Intervention

Inhaled medical grade normoxic gas (FiO2 = 0.21; DIN 02238755 Air Liquid Healthcare, Montreal, Quebec, Canada).

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Queen's UniversityLead Sponsor

365 Previous Clinical Trials

120,401 Total Patients Enrolled

Dr. Denis O'DonnellLead Sponsor

6 Previous Clinical Trials

221 Total Patients Enrolled

Denis E O'Donnell, MDPrincipal InvestigatorDirector Respiratory Investigation Unit, Professor

6 Previous Clinical Trials

129 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can participants still join this investigation?

"Affirmative. Clinicaltrials.gov conveys that the study, initially published on May 14th 2021, is currently enrolling participants. Specifically, 20 patients are needed from 1 research facility."

Answered by AI

What is the intended outcome of this experiment?

"The primary metric which is being monitored over the course of this trial to assess its efficacy is Dyspnea Intensity. Other secondary measurements include Inspiratory Capacity, Partial Pressure of Arterialized Carbon Dioxide (PaCO2) and Ventilation. These assessments will be conducted at various points during a standard Cardiopulmonary Exercise Test (CPET), including rest, isotime and end-exercise."

Answered by AI

Has any previous research been conducted with the use of Inhaled Nitric Oxide?

"Presently, 21 clinical trials exploring Inhaled Nitric Oxide are underway; 8 of them in their final stage. Most notably, 97 different medical sites have started investigations into this treatment with the bulk based in Anchorage, Alaska."

Answered by AI

How many participants have been enlisted for this research endeavor?

"Affirmative. The details available on clinicaltrials.gov demonstrate that this medical trial, first posted in May 2021, is actively looking for enrollees. There are 20 places open at a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Inhaled Nitric Oxide (iNO) in Post-Pulmonary Embolism (Post-PE)

Dr. Denis O'Donnell 2021. "Inhaled Nitric Oxide (iNO) in Post-Pulmonary Embolism (Post-PE)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04920695.