Angiotensin-(1-7) for High Blood Pressure

Phase-Based Progress Estimates
High Blood Pressure+1 MoreAngiotensin-(1-7) - Drug
18 - 60
All Sexes
What conditions do you have?

Study Summary

This trial will test if angiotensin-(1-7) can help improve cardiovascular health for people with obesity and high blood pressure.

Eligible Conditions
  • High Blood Pressure
  • Obesity

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: 30 minutes

15 minutes including baseline, cuff inflation, and reactive hyperemia
Change in brachial artery diameter with reactive hyperemia
20 minutes
Change in coronary blood velocity to the cold pressor test
Change in muscle sympathetic nerve activity to the cold pressor test
Change in systolic and diastolic blood pressure to the cold pressor test
30 minutes
Heart Rate Variability
5 minutes
Circulating catecholamines

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

1 of 2
1 of 2

Experimental Treatment

Non-Treatment Group

24 Total Participants · 2 Treatment Groups

Primary Treatment: Angiotensin-(1-7) · Has Placebo Group · Phase < 1

Experimental Group · 1 Intervention: Angiotensin-(1-7) · Intervention Types: Drug
PlaceboComparator Group · 1 Intervention: Saline · Intervention Types: Drug
First Studied
Drug Approval Stage
How many patients have taken this drug
Angiotensin II
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 30 minutes

Who is running the clinical trial?

Amy ArnoldLead Sponsor
1 Previous Clinical Trials
30 Total Patients Enrolled
American Heart AssociationOTHER
283 Previous Clinical Trials
5,823,817 Total Patients Enrolled
Amy C Arnold, Ph.D.Principal InvestigatorPenn State College of Medicine
1 Previous Clinical Trials
55 Total Patients Enrolled

Eligibility Criteria

Age 18 - 60 · All Participants · 6 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
tha18-60 This refers to anyone aged between 18 and 60 years old.
The patient has a satisfactory history and physical exam.
This text is about people who have a BMI of 30-40 kg/m2
High blood pressure is when your blood pressure is consistently above 130 over 80

Who else is applying?

What state do they live in?
How old are they?
18 - 65100.0%
What site did they apply to?
Penn State College of Medicine100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%

How responsive is this trial?

Most responsive sites:
  1. Penn State College of Medicine: < 48 hours
Typically responds via
Average response time
  • < 2 Days